A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

Existing adenine and cytosine base editors induce only a single type of modification, limiting the range of DNA alterations that can be created. Here we describe a CRISPR-Cas9-based synchronous programmable adenine and cytosine editor (SPACE) that can concurrently introduce A-to-G and C-to-T substit...

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Detalles Bibliográficos
Autores principales: Grünewald, Julian, Zhou, Ronghao, Lareau, Caleb A., Garcia, Sara P., Iyer, Sowmya, Miller, Bret R., Langner, Lukas M., Hsu, Jonathan Y., Aryee, Martin J., Joung, J. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723518/
https://www.ncbi.nlm.nih.gov/pubmed/32483364
http://dx.doi.org/10.1038/s41587-020-0535-y

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