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Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study

BACKGROUND: Heart-type fatty acid binding protein (H-FABP) has been reported to be a prognostic predictor for cardiovascular outcome in acute coronary syndrome (ACS). However, its prognostic utility in patients with stable coronary artery disease (CAD) has not been well established. The aim of this...

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Autores principales: Zhang, Hui-Wen, Jin, Jing-Lu, Cao, Ye-Xuan, Liu, Hui-Hui, Zhang, Yan, Guo, Yuan-Lin, Wu, Na-Qiong, Zhu, Cheng-Gang, Gao, Ying, Xu, Rui-Xia, Hua, Qi, Li, Yan-Fang, Cui, Chuan-Jue, Liu, Geng, Dong, Qian, Sun, Jing, Li, Jian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723623/
https://www.ncbi.nlm.nih.gov/pubmed/33313094
http://dx.doi.org/10.21037/atm-20-2493
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author Zhang, Hui-Wen
Jin, Jing-Lu
Cao, Ye-Xuan
Liu, Hui-Hui
Zhang, Yan
Guo, Yuan-Lin
Wu, Na-Qiong
Zhu, Cheng-Gang
Gao, Ying
Xu, Rui-Xia
Hua, Qi
Li, Yan-Fang
Cui, Chuan-Jue
Liu, Geng
Dong, Qian
Sun, Jing
Li, Jian-Jun
author_facet Zhang, Hui-Wen
Jin, Jing-Lu
Cao, Ye-Xuan
Liu, Hui-Hui
Zhang, Yan
Guo, Yuan-Lin
Wu, Na-Qiong
Zhu, Cheng-Gang
Gao, Ying
Xu, Rui-Xia
Hua, Qi
Li, Yan-Fang
Cui, Chuan-Jue
Liu, Geng
Dong, Qian
Sun, Jing
Li, Jian-Jun
author_sort Zhang, Hui-Wen
collection PubMed
description BACKGROUND: Heart-type fatty acid binding protein (H-FABP) has been reported to be a prognostic predictor for cardiovascular outcome in acute coronary syndrome (ACS). However, its prognostic utility in patients with stable coronary artery disease (CAD) has not been well established. The aim of this study was to assess the association between H-FABP with the severity of coronary disease and cardiovascular events (CVEs) in patients with stable CAD. METHODS: A total of 4,370 angiography-proven CAD patients were consecutively enrolled. The severity of CAD was assessed by Gensini Score (GS) and the numbers of diseased vessels. The CVEs included cardiovascular death, myocardial infarction, stroke and coronary revascularization. Cox regression analysis with adjusted hazard ratios (HRs) and Kaplan-Meier analysis were used to evaluate the relation of H-FABP to CVEs in this cohort. RESULTS: During a median follow-up of 51 months, 353 CVEs occurred. Overall, patients in the highest levels of H-FABP group had increased rate of multi-vessel stenosis and higher GS compared with those in the lowest group (P<0.05, respectively). Moreover, H-FABP levels were significantly higher in patients with events compared to those without (P<0.001). In Cox regression analysis, elevated H-FABP levels were found to be independently associated with a high risk of CVEs [adjusted HRs: 1.453; 95% confidence intervals (CIs): 1.040–2.029, P=0.028], especially with cardiovascular death (adjusted HRs: 2.865; 95% CI: 1.315–6.243, P=0.008). CONCLUSIONS: Our results demonstrated that H-FABP was also a useful predictor for CVEs in patients with stable CAD, which needed to be verified by further studies.
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spelling pubmed-77236232020-12-10 Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study Zhang, Hui-Wen Jin, Jing-Lu Cao, Ye-Xuan Liu, Hui-Hui Zhang, Yan Guo, Yuan-Lin Wu, Na-Qiong Zhu, Cheng-Gang Gao, Ying Xu, Rui-Xia Hua, Qi Li, Yan-Fang Cui, Chuan-Jue Liu, Geng Dong, Qian Sun, Jing Li, Jian-Jun Ann Transl Med Original Article BACKGROUND: Heart-type fatty acid binding protein (H-FABP) has been reported to be a prognostic predictor for cardiovascular outcome in acute coronary syndrome (ACS). However, its prognostic utility in patients with stable coronary artery disease (CAD) has not been well established. The aim of this study was to assess the association between H-FABP with the severity of coronary disease and cardiovascular events (CVEs) in patients with stable CAD. METHODS: A total of 4,370 angiography-proven CAD patients were consecutively enrolled. The severity of CAD was assessed by Gensini Score (GS) and the numbers of diseased vessels. The CVEs included cardiovascular death, myocardial infarction, stroke and coronary revascularization. Cox regression analysis with adjusted hazard ratios (HRs) and Kaplan-Meier analysis were used to evaluate the relation of H-FABP to CVEs in this cohort. RESULTS: During a median follow-up of 51 months, 353 CVEs occurred. Overall, patients in the highest levels of H-FABP group had increased rate of multi-vessel stenosis and higher GS compared with those in the lowest group (P<0.05, respectively). Moreover, H-FABP levels were significantly higher in patients with events compared to those without (P<0.001). In Cox regression analysis, elevated H-FABP levels were found to be independently associated with a high risk of CVEs [adjusted HRs: 1.453; 95% confidence intervals (CIs): 1.040–2.029, P=0.028], especially with cardiovascular death (adjusted HRs: 2.865; 95% CI: 1.315–6.243, P=0.008). CONCLUSIONS: Our results demonstrated that H-FABP was also a useful predictor for CVEs in patients with stable CAD, which needed to be verified by further studies. AME Publishing Company 2020-11 /pmc/articles/PMC7723623/ /pubmed/33313094 http://dx.doi.org/10.21037/atm-20-2493 Text en 2020 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zhang, Hui-Wen
Jin, Jing-Lu
Cao, Ye-Xuan
Liu, Hui-Hui
Zhang, Yan
Guo, Yuan-Lin
Wu, Na-Qiong
Zhu, Cheng-Gang
Gao, Ying
Xu, Rui-Xia
Hua, Qi
Li, Yan-Fang
Cui, Chuan-Jue
Liu, Geng
Dong, Qian
Sun, Jing
Li, Jian-Jun
Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
title Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
title_full Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
title_fullStr Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
title_full_unstemmed Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
title_short Heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
title_sort heart-type fatty acid binding protein predicts cardiovascular events in patients with stable coronary artery disease: a prospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723623/
https://www.ncbi.nlm.nih.gov/pubmed/33313094
http://dx.doi.org/10.21037/atm-20-2493
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