Unmasking the expression of PD-L1 in Myeloid Derived Suppressor Cells: A case study in lung cancer to discover new drugs with specific on-target efficacy

• PD-L1 displays variation of spatial conformation in response to phorbol ester stimulation, which may confer a critical enhancement in binding affinity. • PD-L1 conformational change may be associated with an immunoregulatory mechanism that affects therapies targeting the PD-1/PD-L1 checkpoint. • E...

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Detalles Bibliográficos
Autores principales: Rico, Laura G., Aguilar Hernández, Andrés, Ward, Michael D., Bradford, Jolene A., Juncà, Jordi, Rosell, Rafael, Petriz, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Letters to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723799/
https://www.ncbi.nlm.nih.gov/pubmed/33395749
http://dx.doi.org/10.1016/j.tranon.2020.100969

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