Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case

A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plas...

Descripción completa

Detalles Bibliográficos
Autores principales: Adachi, Yuichi, Takimoto, Takayuki, Takeda, Maiko, Matsumoto, Kinnosuke, Takeuchi, Naoko, Kagawa, Tomoko, Sakamoto, Tetsuki, Kasai, Takahiko, Sugimoto, Chikatoshi, Inoue, Yasushi, Tachibana, Kazunobu, Arai, Toru, Inoue, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723813/
https://www.ncbi.nlm.nih.gov/pubmed/33318921
http://dx.doi.org/10.1016/j.rmcr.2020.101313
Descripción
Sumario:A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plasma cells between follicles, and AL kappa amyloid deposition. Genetic examination detected MYD88 L265P mutation. Our diagnosis was lymphoplasmacytic lymphoma (LPL), involving the mediastinum and the lung, followed by amyloidosis. Mutation analysis, in addition to conventional histological evaluation, was useful for a precise diagnosis.

Ejemplares similares