Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case

A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plas...

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Autores principales: Adachi, Yuichi, Takimoto, Takayuki, Takeda, Maiko, Matsumoto, Kinnosuke, Takeuchi, Naoko, Kagawa, Tomoko, Sakamoto, Tetsuki, Kasai, Takahiko, Sugimoto, Chikatoshi, Inoue, Yasushi, Tachibana, Kazunobu, Arai, Toru, Inoue, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723813/
https://www.ncbi.nlm.nih.gov/pubmed/33318921
http://dx.doi.org/10.1016/j.rmcr.2020.101313
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author Adachi, Yuichi
Takimoto, Takayuki
Takeda, Maiko
Matsumoto, Kinnosuke
Takeuchi, Naoko
Kagawa, Tomoko
Sakamoto, Tetsuki
Kasai, Takahiko
Sugimoto, Chikatoshi
Inoue, Yasushi
Tachibana, Kazunobu
Arai, Toru
Inoue, Yoshikazu
author_facet Adachi, Yuichi
Takimoto, Takayuki
Takeda, Maiko
Matsumoto, Kinnosuke
Takeuchi, Naoko
Kagawa, Tomoko
Sakamoto, Tetsuki
Kasai, Takahiko
Sugimoto, Chikatoshi
Inoue, Yasushi
Tachibana, Kazunobu
Arai, Toru
Inoue, Yoshikazu
author_sort Adachi, Yuichi
collection PubMed
description A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plasma cells between follicles, and AL kappa amyloid deposition. Genetic examination detected MYD88 L265P mutation. Our diagnosis was lymphoplasmacytic lymphoma (LPL), involving the mediastinum and the lung, followed by amyloidosis. Mutation analysis, in addition to conventional histological evaluation, was useful for a precise diagnosis.
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spelling pubmed-77238132020-12-13 Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case Adachi, Yuichi Takimoto, Takayuki Takeda, Maiko Matsumoto, Kinnosuke Takeuchi, Naoko Kagawa, Tomoko Sakamoto, Tetsuki Kasai, Takahiko Sugimoto, Chikatoshi Inoue, Yasushi Tachibana, Kazunobu Arai, Toru Inoue, Yoshikazu Respir Med Case Rep Case Report A 60-year-old man was admitted for ground glass opacity in the lower lung field and mediastinal lymphadenopathy. Blood tests revealed elevated serum IgM levels, and the urine test detected Bence-Jones protein. Surgical biopsy from the mediastinal lymph node and lung showed small lymphocytes and plasma cells between follicles, and AL kappa amyloid deposition. Genetic examination detected MYD88 L265P mutation. Our diagnosis was lymphoplasmacytic lymphoma (LPL), involving the mediastinum and the lung, followed by amyloidosis. Mutation analysis, in addition to conventional histological evaluation, was useful for a precise diagnosis. Elsevier 2020-12-01 /pmc/articles/PMC7723813/ /pubmed/33318921 http://dx.doi.org/10.1016/j.rmcr.2020.101313 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Adachi, Yuichi
Takimoto, Takayuki
Takeda, Maiko
Matsumoto, Kinnosuke
Takeuchi, Naoko
Kagawa, Tomoko
Sakamoto, Tetsuki
Kasai, Takahiko
Sugimoto, Chikatoshi
Inoue, Yasushi
Tachibana, Kazunobu
Arai, Toru
Inoue, Yoshikazu
Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case
title Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case
title_full Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case
title_fullStr Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case
title_full_unstemmed Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case
title_short Lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: A surgically and genetically proven case
title_sort lymphoplasmacytic lymphoma involving the mediastinum and the lung, followed by amyloidosis: a surgically and genetically proven case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723813/
https://www.ncbi.nlm.nih.gov/pubmed/33318921
http://dx.doi.org/10.1016/j.rmcr.2020.101313
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