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Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group
It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723989/ https://www.ncbi.nlm.nih.gov/pubmed/33293520 http://dx.doi.org/10.1038/s41398-020-01109-5 |
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author | Leerssen, Jeanne Blanken, Tessa F. Pozzi, Elena Jahanshad, Neda Aftanas, Lyubomir Andreassen, Ole A. Baune, Bernhard T. Brack, Ivan Carballedo, Angela Ching, Christopher R. K. Dannlowski, Udo Dohm, Katharina Enneking, Verena Filimonova, Elena Fingas, Stella M. Frodl, Thomas Godlewska, Beata R. Goltermann, Janik Gotlib, Ian H. Grotegerd, Dominik Gruber, Oliver Harris, Mathew A. Hatton, Sean N. Hawkins, Emma Hickie, Ian B. Jaworska, Natalia Kircher, Tilo Krug, Axel Lagopoulos, Jim Lemke, Hannah Li, Meng MacMaster, Frank P. McIntosh, Andrew M. McLellan, Quinn Meinert, Susanne Mwangi, Benson Nenadić, Igor Osipov, Evgeny Portella, Maria J. Redlich, Ronny Repple, Jonathan Sacchet, Matthew D. Sämann, Philipp G. Simulionyte, Egle Soares, Jair C. Walter, Martin Watanabe, Norio Whalley, Heather C. Yüksel, Dilara Veltman, Dick J. Thompson, Paul M. Schmaal, Lianne Van Someren, Eus J. W. |
author_facet | Leerssen, Jeanne Blanken, Tessa F. Pozzi, Elena Jahanshad, Neda Aftanas, Lyubomir Andreassen, Ole A. Baune, Bernhard T. Brack, Ivan Carballedo, Angela Ching, Christopher R. K. Dannlowski, Udo Dohm, Katharina Enneking, Verena Filimonova, Elena Fingas, Stella M. Frodl, Thomas Godlewska, Beata R. Goltermann, Janik Gotlib, Ian H. Grotegerd, Dominik Gruber, Oliver Harris, Mathew A. Hatton, Sean N. Hawkins, Emma Hickie, Ian B. Jaworska, Natalia Kircher, Tilo Krug, Axel Lagopoulos, Jim Lemke, Hannah Li, Meng MacMaster, Frank P. McIntosh, Andrew M. McLellan, Quinn Meinert, Susanne Mwangi, Benson Nenadić, Igor Osipov, Evgeny Portella, Maria J. Redlich, Ronny Repple, Jonathan Sacchet, Matthew D. Sämann, Philipp G. Simulionyte, Egle Soares, Jair C. Walter, Martin Watanabe, Norio Whalley, Heather C. Yüksel, Dilara Veltman, Dick J. Thompson, Paul M. Schmaal, Lianne Van Someren, Eus J. W. |
author_sort | Leerssen, Jeanne |
collection | PubMed |
description | It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD. |
format | Online Article Text |
id | pubmed-7723989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77239892020-12-17 Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group Leerssen, Jeanne Blanken, Tessa F. Pozzi, Elena Jahanshad, Neda Aftanas, Lyubomir Andreassen, Ole A. Baune, Bernhard T. Brack, Ivan Carballedo, Angela Ching, Christopher R. K. Dannlowski, Udo Dohm, Katharina Enneking, Verena Filimonova, Elena Fingas, Stella M. Frodl, Thomas Godlewska, Beata R. Goltermann, Janik Gotlib, Ian H. Grotegerd, Dominik Gruber, Oliver Harris, Mathew A. Hatton, Sean N. Hawkins, Emma Hickie, Ian B. Jaworska, Natalia Kircher, Tilo Krug, Axel Lagopoulos, Jim Lemke, Hannah Li, Meng MacMaster, Frank P. McIntosh, Andrew M. McLellan, Quinn Meinert, Susanne Mwangi, Benson Nenadić, Igor Osipov, Evgeny Portella, Maria J. Redlich, Ronny Repple, Jonathan Sacchet, Matthew D. Sämann, Philipp G. Simulionyte, Egle Soares, Jair C. Walter, Martin Watanabe, Norio Whalley, Heather C. Yüksel, Dilara Veltman, Dick J. Thompson, Paul M. Schmaal, Lianne Van Someren, Eus J. W. Transl Psychiatry Article It has been difficult to find robust brain structural correlates of the overall severity of major depressive disorder (MDD). We hypothesized that specific symptoms may better reveal correlates and investigated this for the severity of insomnia, both a key symptom and a modifiable major risk factor of MDD. Cortical thickness, surface area and subcortical volumes were assessed from T1-weighted brain magnetic resonance imaging (MRI) scans of 1053 MDD patients (age range 13-79 years) from 15 cohorts within the ENIGMA MDD Working Group. Insomnia severity was measured by summing the insomnia items of the Hamilton Depression Rating Scale (HDRS). Symptom specificity was evaluated with correlates of overall depression severity. Disease specificity was evaluated in two independent samples comprising 2108 healthy controls, and in 260 clinical controls with bipolar disorder. Results showed that MDD patients with more severe insomnia had a smaller cortical surface area, mostly driven by the right insula, left inferior frontal gyrus pars triangularis, left frontal pole, right superior parietal cortex, right medial orbitofrontal cortex, and right supramarginal gyrus. Associations were specific for insomnia severity, and were not found for overall depression severity. Associations were also specific to MDD; healthy controls and clinical controls showed differential insomnia severity association profiles. The findings indicate that MDD patients with more severe insomnia show smaller surfaces in several frontoparietal cortical areas. While explained variance remains small, symptom-specific associations could bring us closer to clues on underlying biological phenomena of MDD. Nature Publishing Group UK 2020-12-08 /pmc/articles/PMC7723989/ /pubmed/33293520 http://dx.doi.org/10.1038/s41398-020-01109-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Leerssen, Jeanne Blanken, Tessa F. Pozzi, Elena Jahanshad, Neda Aftanas, Lyubomir Andreassen, Ole A. Baune, Bernhard T. Brack, Ivan Carballedo, Angela Ching, Christopher R. K. Dannlowski, Udo Dohm, Katharina Enneking, Verena Filimonova, Elena Fingas, Stella M. Frodl, Thomas Godlewska, Beata R. Goltermann, Janik Gotlib, Ian H. Grotegerd, Dominik Gruber, Oliver Harris, Mathew A. Hatton, Sean N. Hawkins, Emma Hickie, Ian B. Jaworska, Natalia Kircher, Tilo Krug, Axel Lagopoulos, Jim Lemke, Hannah Li, Meng MacMaster, Frank P. McIntosh, Andrew M. McLellan, Quinn Meinert, Susanne Mwangi, Benson Nenadić, Igor Osipov, Evgeny Portella, Maria J. Redlich, Ronny Repple, Jonathan Sacchet, Matthew D. Sämann, Philipp G. Simulionyte, Egle Soares, Jair C. Walter, Martin Watanabe, Norio Whalley, Heather C. Yüksel, Dilara Veltman, Dick J. Thompson, Paul M. Schmaal, Lianne Van Someren, Eus J. W. Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group |
title | Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group |
title_full | Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group |
title_fullStr | Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group |
title_full_unstemmed | Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group |
title_short | Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group |
title_sort | brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the enigma mdd working group |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723989/ https://www.ncbi.nlm.nih.gov/pubmed/33293520 http://dx.doi.org/10.1038/s41398-020-01109-5 |
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