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Quantification of the Resilience and Vulnerability of HIV-1 Native Glycan Shield at Atomistic Detail

Dense surface glycosylation on the HIV-1 envelope (Env) protein acts as a shield from the adaptive immune system. However, the molecular complexity and flexibility of glycans make experimental studies a challenge. Here we have integrated high-throughput atomistic modeling of fully glycosylated HIV-1...

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Detalles Bibliográficos
Autores principales: Chakraborty, Srirupa, Berndsen, Zachary T., Hengartner, Nicolas W., Korber, Bette T., Ward, Andrew B., Gnanakaran, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724196/
https://www.ncbi.nlm.nih.gov/pubmed/33319171
http://dx.doi.org/10.1016/j.isci.2020.101836