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The evolutionary history and global spatio-temporal dynamics of potato virus Y

Potato virus Y (PVY) is a destructive plant pathogen that causes considerable losses to global potato and tobacco production. Although the molecular structure of PVY is well characterized, the evolutionary and global transmission dynamics of this virus remain poorly understood. We investigated the p...

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Autores principales: Gao, Fangluan, Kawakubo, Shusuke, Ho, Simon Y W, Ohshima, Kazusato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724251/
https://www.ncbi.nlm.nih.gov/pubmed/33324488
http://dx.doi.org/10.1093/ve/veaa056
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author Gao, Fangluan
Kawakubo, Shusuke
Ho, Simon Y W
Ohshima, Kazusato
author_facet Gao, Fangluan
Kawakubo, Shusuke
Ho, Simon Y W
Ohshima, Kazusato
author_sort Gao, Fangluan
collection PubMed
description Potato virus Y (PVY) is a destructive plant pathogen that causes considerable losses to global potato and tobacco production. Although the molecular structure of PVY is well characterized, the evolutionary and global transmission dynamics of this virus remain poorly understood. We investigated the phylodynamics of the virus by analysing 253 nucleotide sequences of the genes encoding the third protein (P3), cylindrical inclusion protein (CI), and the nuclear inclusion protein (NIb). Our Bayesian phylogenetic analyses showed that the mean substitution rates of different regions of the genome ranged from 8.50 × 10(−5) to 1.34 × 10(−4) substitutions/site/year, whereas the time to the most recent common ancestor of PVY varied with the length of the genomic regions and with the number of viral isolates being analysed. Our phylogeographic analysis showed that the PVY population originated in South America and was introduced into Europe in the 19th century, from where it spread around the globe. The migration pathways of PVY correlate well with the trade routes of potato tubers, suggesting that the global spread of PVY is associated with human activities.
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spelling pubmed-77242512020-12-14 The evolutionary history and global spatio-temporal dynamics of potato virus Y Gao, Fangluan Kawakubo, Shusuke Ho, Simon Y W Ohshima, Kazusato Virus Evol Research Article Potato virus Y (PVY) is a destructive plant pathogen that causes considerable losses to global potato and tobacco production. Although the molecular structure of PVY is well characterized, the evolutionary and global transmission dynamics of this virus remain poorly understood. We investigated the phylodynamics of the virus by analysing 253 nucleotide sequences of the genes encoding the third protein (P3), cylindrical inclusion protein (CI), and the nuclear inclusion protein (NIb). Our Bayesian phylogenetic analyses showed that the mean substitution rates of different regions of the genome ranged from 8.50 × 10(−5) to 1.34 × 10(−4) substitutions/site/year, whereas the time to the most recent common ancestor of PVY varied with the length of the genomic regions and with the number of viral isolates being analysed. Our phylogeographic analysis showed that the PVY population originated in South America and was introduced into Europe in the 19th century, from where it spread around the globe. The migration pathways of PVY correlate well with the trade routes of potato tubers, suggesting that the global spread of PVY is associated with human activities. Oxford University Press 2020-11-21 /pmc/articles/PMC7724251/ /pubmed/33324488 http://dx.doi.org/10.1093/ve/veaa056 Text en © The Author(s) 2020. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gao, Fangluan
Kawakubo, Shusuke
Ho, Simon Y W
Ohshima, Kazusato
The evolutionary history and global spatio-temporal dynamics of potato virus Y
title The evolutionary history and global spatio-temporal dynamics of potato virus Y
title_full The evolutionary history and global spatio-temporal dynamics of potato virus Y
title_fullStr The evolutionary history and global spatio-temporal dynamics of potato virus Y
title_full_unstemmed The evolutionary history and global spatio-temporal dynamics of potato virus Y
title_short The evolutionary history and global spatio-temporal dynamics of potato virus Y
title_sort evolutionary history and global spatio-temporal dynamics of potato virus y
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724251/
https://www.ncbi.nlm.nih.gov/pubmed/33324488
http://dx.doi.org/10.1093/ve/veaa056
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