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The efficacy of vitamin E in reducing non-alcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population. Clinical trials have questioned the role of vitamin E in the treatment of NAFLD with or without other interventions, with still no firm conclusion reached. This study aims to examine the efficiency of vitamin...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724271/ https://www.ncbi.nlm.nih.gov/pubmed/33335561 http://dx.doi.org/10.1177/1756284820974917 |
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author | Abdel-Maboud, Mohamed Menshawy, Amr Menshawy, Esraa Emara, Amany Alshandidy, Mohamed Eid, Muhammad |
author_facet | Abdel-Maboud, Mohamed Menshawy, Amr Menshawy, Esraa Emara, Amany Alshandidy, Mohamed Eid, Muhammad |
author_sort | Abdel-Maboud, Mohamed |
collection | PubMed |
description | BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population. Clinical trials have questioned the role of vitamin E in the treatment of NAFLD with or without other interventions, with still no firm conclusion reached. This study aims to examine the efficiency of vitamin E alone or combined in the management of NAFLD. METHODS: We performed a systematic literature search on PubMed, Scopus, Embase, Ovid, EBSCO host, Science Direct, Web of Science, and Cochrane CENTRAL for randomized controlled trials (RCTs) of the role of vitamin E alone or combined in NAFLD patients. Extracted manuscripts reported data on biochemical, histological, anthropometric, and metabolic outcomes. Baseline characteristics, settings, dosage, and frequency were also collected. RESEARCH: A total of 1317 patients from 15 RCTs were included in our systematic review and meta-analysis. Vitamin E was superior at improving alanine aminotransferase (ALT), aspartate aminotransferase (AST), NAFLD activity score (NAS), and fibrosis in short- and long-term follow up in the adult population, and long-term follow up in the pediatric population. Improvements in metabolic outcomes were best noticed in pediatric patients. Results from multiple regression models showed a significant association between ALT-AST levels and vitamin E dose. AST levels had a significant effect on NAS, and patients with a baseline AST > 50 IU/l showed more promising results. Changes in weight and body mass index (BMI) were strongly associated with changes in NAS. CONCLUSION: Current evidence affirms that vitamin E – whether alone or combined – improves biochemical and histological outcomes in adults and pediatric patients. |
format | Online Article Text |
id | pubmed-7724271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-77242712020-12-16 The efficacy of vitamin E in reducing non-alcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression Abdel-Maboud, Mohamed Menshawy, Amr Menshawy, Esraa Emara, Amany Alshandidy, Mohamed Eid, Muhammad Therap Adv Gastroenterol Insights into the Management of Patients with Liver Disease BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) affects up to 30% of the population. Clinical trials have questioned the role of vitamin E in the treatment of NAFLD with or without other interventions, with still no firm conclusion reached. This study aims to examine the efficiency of vitamin E alone or combined in the management of NAFLD. METHODS: We performed a systematic literature search on PubMed, Scopus, Embase, Ovid, EBSCO host, Science Direct, Web of Science, and Cochrane CENTRAL for randomized controlled trials (RCTs) of the role of vitamin E alone or combined in NAFLD patients. Extracted manuscripts reported data on biochemical, histological, anthropometric, and metabolic outcomes. Baseline characteristics, settings, dosage, and frequency were also collected. RESEARCH: A total of 1317 patients from 15 RCTs were included in our systematic review and meta-analysis. Vitamin E was superior at improving alanine aminotransferase (ALT), aspartate aminotransferase (AST), NAFLD activity score (NAS), and fibrosis in short- and long-term follow up in the adult population, and long-term follow up in the pediatric population. Improvements in metabolic outcomes were best noticed in pediatric patients. Results from multiple regression models showed a significant association between ALT-AST levels and vitamin E dose. AST levels had a significant effect on NAS, and patients with a baseline AST > 50 IU/l showed more promising results. Changes in weight and body mass index (BMI) were strongly associated with changes in NAS. CONCLUSION: Current evidence affirms that vitamin E – whether alone or combined – improves biochemical and histological outcomes in adults and pediatric patients. SAGE Publications 2020-12-07 /pmc/articles/PMC7724271/ /pubmed/33335561 http://dx.doi.org/10.1177/1756284820974917 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Insights into the Management of Patients with Liver Disease Abdel-Maboud, Mohamed Menshawy, Amr Menshawy, Esraa Emara, Amany Alshandidy, Mohamed Eid, Muhammad The efficacy of vitamin E in reducing non-alcoholic fatty liver disease: a systematic review, meta-analysis, and meta-regression |
title | The efficacy of vitamin E in reducing non-alcoholic fatty liver
disease: a systematic review, meta-analysis, and meta-regression |
title_full | The efficacy of vitamin E in reducing non-alcoholic fatty liver
disease: a systematic review, meta-analysis, and meta-regression |
title_fullStr | The efficacy of vitamin E in reducing non-alcoholic fatty liver
disease: a systematic review, meta-analysis, and meta-regression |
title_full_unstemmed | The efficacy of vitamin E in reducing non-alcoholic fatty liver
disease: a systematic review, meta-analysis, and meta-regression |
title_short | The efficacy of vitamin E in reducing non-alcoholic fatty liver
disease: a systematic review, meta-analysis, and meta-regression |
title_sort | efficacy of vitamin e in reducing non-alcoholic fatty liver
disease: a systematic review, meta-analysis, and meta-regression |
topic | Insights into the Management of Patients with Liver Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724271/ https://www.ncbi.nlm.nih.gov/pubmed/33335561 http://dx.doi.org/10.1177/1756284820974917 |
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