Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads

Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 comp...

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Detalles Bibliográficos
Autores principales: Hoevenaar, Martijn, Goossens, Dolf, Roorda, Janne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
COVID-19 and the Renin-Angiotensin-Aldosterone System
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724427/
https://www.ncbi.nlm.nih.gov/pubmed/33283602
http://dx.doi.org/10.1177/1470320320979097
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author Hoevenaar, Martijn
Goossens, Dolf
Roorda, Janne
author_facet Hoevenaar, Martijn
Goossens, Dolf
Roorda, Janne
author_sort Hoevenaar, Martijn
collection PubMed
description Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 complications (e.g. ARDS and thrombosis), and potential therapeutic targets for pharmacological intervention, will be reviewed.
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spelling pubmed-77244272020-12-16 Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads Hoevenaar, Martijn Goossens, Dolf Roorda, Janne J Renin Angiotensin Aldosterone Syst COVID-19 and the Renin-Angiotensin-Aldosterone System Because of the current COVID-19-pandemic, the world is currently being held hostage in various lockdowns. ACE2 facilitates SARS-CoV-2 cell-entry, and is at the very center of several pathophysiological pathways regarding the RAAS, CS, KKS, T2DM, and IL-6. Their interactions with severe COVID-19 complications (e.g. ARDS and thrombosis), and potential therapeutic targets for pharmacological intervention, will be reviewed. SAGE Publications 2020-12-06 /pmc/articles/PMC7724427/ /pubmed/33283602 http://dx.doi.org/10.1177/1470320320979097 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle COVID-19 and the Renin-Angiotensin-Aldosterone System
Hoevenaar, Martijn
Goossens, Dolf
Roorda, Janne
Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
title Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
title_full Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
title_fullStr Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
title_full_unstemmed Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
title_short Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads
title_sort angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex covid-19 pathophysiological crossroads
topic COVID-19 and the Renin-Angiotensin-Aldosterone System
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724427/
https://www.ncbi.nlm.nih.gov/pubmed/33283602
http://dx.doi.org/10.1177/1470320320979097
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