Two Functional Axes of Feedback-Enforced PRC2 Recruitment in Mouse Embryonic Stem Cells

Polycomb Repressive Complex 2 (PRC2) plays an essential role in gene repression during development, catalyzing H3 lysine 27 trimethylation (H3K27me3). MTF2 in the PRC2.1 sub-complex, and JARID2 in PRC2.2, are central in core PRC2 recruitment to target genes in mouse embryonic stem cells (mESCs). To...

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Detalles Bibliográficos
Autores principales: Perino, Matteo, van Mierlo, Guido, Loh, Chet, Wardle, Sandra M.T., Zijlmans, Dick W., Marks, Hendrik, Veenstra, Gert Jan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724473/
https://www.ncbi.nlm.nih.gov/pubmed/32763159
http://dx.doi.org/10.1016/j.stemcr.2020.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724473/
https://www.ncbi.nlm.nih.gov/pubmed/32763159
http://dx.doi.org/10.1016/j.stemcr.2020.07.007

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