Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2

The SARS-CoV-2 infection is spreading rapidly worldwide. Efficacious antiviral therapeutics against SARS-CoV-2 is urgently needed. Here, we discovered that protoporphyrin IX (PpIX) and verteporfin, two Food and Drug Administration (FDA)-approved drugs, completely inhibited the cytopathic effect prod...

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Detalles Bibliográficos
Autores principales: Gu, Chenjian, Wu, Yang, Guo, Huimin, Zhu, Yuanfei, Xu, Wei, Wang, Yuyan, Zhou, Yu, Sun, Zhiping, Cai, Xia, Li, Yutang, Liu, Jing, Huang, Zhong, Yuan, Zhenghong, Zhang, Rong, Deng, Qiang, Qu, Di, Xie, Youhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science China Press. Published by Elsevier B.V. and Science China Press. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724564/
https://www.ncbi.nlm.nih.gov/pubmed/33318880
http://dx.doi.org/10.1016/j.scib.2020.12.005

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