Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo

SIMPLE SUMMARY: There is an unmet medical need for new and potent pharmacological inhibitor drugs for the protein Stat5 that would be orally bioavailable for treatment of several different cancers. Previous work has established a critical role for Stat5 in molecular and clinical progression of prost...

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Detalles Bibliográficos
Autores principales: Maranto, Cristina, Udhane, Vindhya, Jia, Jing, Verma, Ranjit, Müller-Newen, Gerhard, LaViolette, Peter S., Pereckas, Michael, Sabharwal, Lavannya, Terhune, Scott, Pattabiraman, Nagarajan, Njar, Vincent C.O., Imig, John D., Wang, Liang, Nevalainen, Marja T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724566/
https://www.ncbi.nlm.nih.gov/pubmed/33217941
http://dx.doi.org/10.3390/cancers12113412

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