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Targeting RNA structures in diseases with small molecules
RNA is crucial for gene expression and regulation. Recent advances in understanding of RNA biochemistry, structure and molecular biology have revealed the importance of RNA structure in cellular processes and diseases. Various approaches to discovering drug-like small molecules that target RNA struc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724634/ https://www.ncbi.nlm.nih.gov/pubmed/33078198 http://dx.doi.org/10.1042/EBC20200011 |
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author | Shao, Yanqiu Zhang, Qiangfeng Cliff |
author_facet | Shao, Yanqiu Zhang, Qiangfeng Cliff |
author_sort | Shao, Yanqiu |
collection | PubMed |
description | RNA is crucial for gene expression and regulation. Recent advances in understanding of RNA biochemistry, structure and molecular biology have revealed the importance of RNA structure in cellular processes and diseases. Various approaches to discovering drug-like small molecules that target RNA structure have been developed. This review provides a brief introduction to RNA structural biology and how RNA structures function as disease regulators. We summarize approaches to targeting RNA with small molecules and highlight their advantages, shortcomings and therapeutic potential. |
format | Online Article Text |
id | pubmed-7724634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77246342020-12-16 Targeting RNA structures in diseases with small molecules Shao, Yanqiu Zhang, Qiangfeng Cliff Essays Biochem RNA RNA is crucial for gene expression and regulation. Recent advances in understanding of RNA biochemistry, structure and molecular biology have revealed the importance of RNA structure in cellular processes and diseases. Various approaches to discovering drug-like small molecules that target RNA structure have been developed. This review provides a brief introduction to RNA structural biology and how RNA structures function as disease regulators. We summarize approaches to targeting RNA with small molecules and highlight their advantages, shortcomings and therapeutic potential. Portland Press Ltd. 2020-12 2020-12-07 /pmc/articles/PMC7724634/ /pubmed/33078198 http://dx.doi.org/10.1042/EBC20200011 Text en © 2020 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the . |
spellingShingle | RNA Shao, Yanqiu Zhang, Qiangfeng Cliff Targeting RNA structures in diseases with small molecules |
title | Targeting RNA structures in diseases with small molecules |
title_full | Targeting RNA structures in diseases with small molecules |
title_fullStr | Targeting RNA structures in diseases with small molecules |
title_full_unstemmed | Targeting RNA structures in diseases with small molecules |
title_short | Targeting RNA structures in diseases with small molecules |
title_sort | targeting rna structures in diseases with small molecules |
topic | RNA |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724634/ https://www.ncbi.nlm.nih.gov/pubmed/33078198 http://dx.doi.org/10.1042/EBC20200011 |
work_keys_str_mv | AT shaoyanqiu targetingrnastructuresindiseaseswithsmallmolecules AT zhangqiangfengcliff targetingrnastructuresindiseaseswithsmallmolecules |