Cargando…
Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity
BACKGROUND: Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been reported in detail. METHODS: All patients aged ≥ 65 years with M or VS who unde...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724716/ https://www.ncbi.nlm.nih.gov/pubmed/33298109 http://dx.doi.org/10.1186/s13014-020-01714-0 |
_version_ | 1783620578772516864 |
---|---|
author | Rueß, Daniel Weyer, Vera Tutunji, Juman Grau, Stefan Kocher, Martin Hoevels, Mauritius Treuer, Harald Baues, Christian Ruge, Maximilian I. |
author_facet | Rueß, Daniel Weyer, Vera Tutunji, Juman Grau, Stefan Kocher, Martin Hoevels, Mauritius Treuer, Harald Baues, Christian Ruge, Maximilian I. |
author_sort | Rueß, Daniel |
collection | PubMed |
description | BACKGROUND: Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been reported in detail. METHODS: All patients aged ≥ 65 years with M or VS who underwent single fraction SRS were included. Patient data were analyzed in terms of clinical tumor control and incidence of early and late treatment related complications, which were graded according to the Common Terminology Criteria for Adverse Events (CTCAE), RESULTS: We identified 245 patients with benign brain tumors (129 M and 116 VS, median tumor volume 2.9 ml, range 0.1–28). The median age was 71 years (range 65–86) and the mean follow-up times were 42 months (range 2–181). Tumors were irradiated with a median dose of 12.4 Gy. Actuarial clinical and radiological tumor control rates at 2, 5, and 10 years after SRS were 98%, 93%, and 88%, respectively. Recurrent tumors after previous treatment had a higher probability of post-radiosurgical progression (p < 0.001). Permanent toxicity (CTCAE I/II) were noted in 5.7%. No severe adverse events were observed during early and late follow up, although patients > 70 years had a slightly higher risk for toxicity (p = 0.027). The presence and extent of co-morbidities had no significant influence on local tumor control or toxicity. CONCLUSION: SRS provides favorable tumor control with low risk for treatment-related severe complications. Thus, SRS should always be considered as treatment option for benign intracranial tumors (meningiomas, schwannomas), especially in the group of elderly patients. |
format | Online Article Text |
id | pubmed-7724716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77247162020-12-09 Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity Rueß, Daniel Weyer, Vera Tutunji, Juman Grau, Stefan Kocher, Martin Hoevels, Mauritius Treuer, Harald Baues, Christian Ruge, Maximilian I. Radiat Oncol Research BACKGROUND: Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been reported in detail. METHODS: All patients aged ≥ 65 years with M or VS who underwent single fraction SRS were included. Patient data were analyzed in terms of clinical tumor control and incidence of early and late treatment related complications, which were graded according to the Common Terminology Criteria for Adverse Events (CTCAE), RESULTS: We identified 245 patients with benign brain tumors (129 M and 116 VS, median tumor volume 2.9 ml, range 0.1–28). The median age was 71 years (range 65–86) and the mean follow-up times were 42 months (range 2–181). Tumors were irradiated with a median dose of 12.4 Gy. Actuarial clinical and radiological tumor control rates at 2, 5, and 10 years after SRS were 98%, 93%, and 88%, respectively. Recurrent tumors after previous treatment had a higher probability of post-radiosurgical progression (p < 0.001). Permanent toxicity (CTCAE I/II) were noted in 5.7%. No severe adverse events were observed during early and late follow up, although patients > 70 years had a slightly higher risk for toxicity (p = 0.027). The presence and extent of co-morbidities had no significant influence on local tumor control or toxicity. CONCLUSION: SRS provides favorable tumor control with low risk for treatment-related severe complications. Thus, SRS should always be considered as treatment option for benign intracranial tumors (meningiomas, schwannomas), especially in the group of elderly patients. BioMed Central 2020-12-09 /pmc/articles/PMC7724716/ /pubmed/33298109 http://dx.doi.org/10.1186/s13014-020-01714-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Rueß, Daniel Weyer, Vera Tutunji, Juman Grau, Stefan Kocher, Martin Hoevels, Mauritius Treuer, Harald Baues, Christian Ruge, Maximilian I. Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
title | Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
title_full | Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
title_fullStr | Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
title_full_unstemmed | Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
title_short | Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
title_sort | stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724716/ https://www.ncbi.nlm.nih.gov/pubmed/33298109 http://dx.doi.org/10.1186/s13014-020-01714-0 |
work_keys_str_mv | AT rueßdaniel stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT weyervera stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT tutunjijuman stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT graustefan stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT kochermartin stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT hoevelsmauritius stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT treuerharald stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT baueschristian stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity AT rugemaximiliani stereotacticradiosurgeryofbenignbraintumorsinelderlypatientsevaluationofoutcomeandtoxicity |