Cargando…

Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs

BACKGROUND: Monovalent meningococcal C conjugate vaccine (MCCV) was introduced into the routine immunization program in many countries in Europe and worldwide following the emergence of meningococcal serogroup C (MenC) in the late 1990s. This systematic literature review summarizes the immediate and...

Descripción completa

Detalles Bibliográficos
Autores principales: Tin Tin Htar, Myint, Jackson, Sally, Balmer, Paul, Serra, Lidia Cristina, Vyse, Andrew, Slack, Mary, Riera-Montes, Margarita, Swerdlow, David L., Findlow, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724720/
https://www.ncbi.nlm.nih.gov/pubmed/33298015
http://dx.doi.org/10.1186/s12889-020-09946-1
_version_ 1783620579728818176
author Tin Tin Htar, Myint
Jackson, Sally
Balmer, Paul
Serra, Lidia Cristina
Vyse, Andrew
Slack, Mary
Riera-Montes, Margarita
Swerdlow, David L.
Findlow, Jamie
author_facet Tin Tin Htar, Myint
Jackson, Sally
Balmer, Paul
Serra, Lidia Cristina
Vyse, Andrew
Slack, Mary
Riera-Montes, Margarita
Swerdlow, David L.
Findlow, Jamie
author_sort Tin Tin Htar, Myint
collection PubMed
description BACKGROUND: Monovalent meningococcal C conjugate vaccine (MCCV) was introduced into the routine immunization program in many countries in Europe and worldwide following the emergence of meningococcal serogroup C (MenC) in the late 1990s. This systematic literature review summarizes the immediate and long-term impact and effectiveness of the different MCCV vaccination schedules and strategies employed. METHODS: We conducted a systematic literature search for peer-reviewed, scientific publications in the databases of MEDLINE (via PubMed), LILACS, and SCIELO. We included studies from countries where MCCV have been introduced in routine vaccination programs and studies providing the impact and effectiveness of MCCV published between 1st January 2001 and 31st October 2017. RESULTS: Forty studies were included in the review; 30 studies reporting impact and 17 reporting effectiveness covering 9 countries (UK, Spain, Italy, Canada, Brazil, Australia, Belgium, Germany and the Netherlands). Following MCCV introduction, significant and immediate reduction of MenC incidence was consistently observed in vaccine eligible ages in all countries with high vaccine uptake. The reduction in non-vaccine eligible ages (especially population > 65 years) through herd protection was generally observed 3–4 years following introduction. Vaccine effectiveness (VE) was mostly assessed through screening methods and ranged from 38 to 100%. The VE was generally highest during the first year after vaccination and waned over time. The VE was better maintained in countries employing catch-up campaigns in older children and adolescents, compared to routine infant only schedules. CONCLUSIONS: MCCV were highly effective, showing a substantial and sustained decrease in MenC invasive meningococcal disease. The epidemiology of meningococcal disease is in constant transition, and some vaccination programs now include adolescents and higher valent vaccines due to the recent increase in cases caused by serogroups not covered by MCCV. Continuous monitoring of meningococcal disease is essential to understand disease evolution in the setting of different vaccination programs.
format Online
Article
Text
id pubmed-7724720
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-77247202020-12-09 Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs Tin Tin Htar, Myint Jackson, Sally Balmer, Paul Serra, Lidia Cristina Vyse, Andrew Slack, Mary Riera-Montes, Margarita Swerdlow, David L. Findlow, Jamie BMC Public Health Research Article BACKGROUND: Monovalent meningococcal C conjugate vaccine (MCCV) was introduced into the routine immunization program in many countries in Europe and worldwide following the emergence of meningococcal serogroup C (MenC) in the late 1990s. This systematic literature review summarizes the immediate and long-term impact and effectiveness of the different MCCV vaccination schedules and strategies employed. METHODS: We conducted a systematic literature search for peer-reviewed, scientific publications in the databases of MEDLINE (via PubMed), LILACS, and SCIELO. We included studies from countries where MCCV have been introduced in routine vaccination programs and studies providing the impact and effectiveness of MCCV published between 1st January 2001 and 31st October 2017. RESULTS: Forty studies were included in the review; 30 studies reporting impact and 17 reporting effectiveness covering 9 countries (UK, Spain, Italy, Canada, Brazil, Australia, Belgium, Germany and the Netherlands). Following MCCV introduction, significant and immediate reduction of MenC incidence was consistently observed in vaccine eligible ages in all countries with high vaccine uptake. The reduction in non-vaccine eligible ages (especially population > 65 years) through herd protection was generally observed 3–4 years following introduction. Vaccine effectiveness (VE) was mostly assessed through screening methods and ranged from 38 to 100%. The VE was generally highest during the first year after vaccination and waned over time. The VE was better maintained in countries employing catch-up campaigns in older children and adolescents, compared to routine infant only schedules. CONCLUSIONS: MCCV were highly effective, showing a substantial and sustained decrease in MenC invasive meningococcal disease. The epidemiology of meningococcal disease is in constant transition, and some vaccination programs now include adolescents and higher valent vaccines due to the recent increase in cases caused by serogroups not covered by MCCV. Continuous monitoring of meningococcal disease is essential to understand disease evolution in the setting of different vaccination programs. BioMed Central 2020-12-09 /pmc/articles/PMC7724720/ /pubmed/33298015 http://dx.doi.org/10.1186/s12889-020-09946-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Tin Tin Htar, Myint
Jackson, Sally
Balmer, Paul
Serra, Lidia Cristina
Vyse, Andrew
Slack, Mary
Riera-Montes, Margarita
Swerdlow, David L.
Findlow, Jamie
Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs
title Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs
title_full Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs
title_fullStr Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs
title_full_unstemmed Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs
title_short Systematic literature review of the impact and effectiveness of monovalent meningococcal C conjugated vaccines when used in routine immunization programs
title_sort systematic literature review of the impact and effectiveness of monovalent meningococcal c conjugated vaccines when used in routine immunization programs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724720/
https://www.ncbi.nlm.nih.gov/pubmed/33298015
http://dx.doi.org/10.1186/s12889-020-09946-1
work_keys_str_mv AT tintinhtarmyint systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT jacksonsally systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT balmerpaul systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT serralidiacristina systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT vyseandrew systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT slackmary systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT rieramontesmargarita systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT swerdlowdavidl systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms
AT findlowjamie systematicliteraturereviewoftheimpactandeffectivenessofmonovalentmeningococcalcconjugatedvaccineswhenusedinroutineimmunizationprograms