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Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection

Enterovirus A71 (EVA71) infection continues to remain a vital threat to global public health, especially in the Asia–Pacific region. It is one of the most predominant pathogens that cause hand, foot, and mouth disease (HFMD), which occurs mainly in children below 5 years old. Although EVA71 prevalen...

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Autores principales: Zhang, Chuanjie, Li, Yawei, Li, Jingfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724827/
https://www.ncbi.nlm.nih.gov/pubmed/33298183
http://dx.doi.org/10.1186/s13578-020-00503-2
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author Zhang, Chuanjie
Li, Yawei
Li, Jingfeng
author_facet Zhang, Chuanjie
Li, Yawei
Li, Jingfeng
author_sort Zhang, Chuanjie
collection PubMed
description Enterovirus A71 (EVA71) infection continues to remain a vital threat to global public health, especially in the Asia–Pacific region. It is one of the most predominant pathogens that cause hand, foot, and mouth disease (HFMD), which occurs mainly in children below 5 years old. Although EVA71 prevalence has decreased sharply in China with the use of vaccines, epidemiological studies still indicate that EVA71 infection involves severe and even fatal HFMD cases. As a result, it remains more fundamental research into the pathogenesis of EVA71 as well as to develop specific anti-viral therapy. Autophagy is a conserved, self-degradation system that is critical for maintaining cellular homeostasis. It involves a variety of biological functions, such as development, cellular differentiation, nutritional starvation, and defense against pathogens. However, accumulating evidence has indicated that EVA71 induces autophagy and hijacks the process of autophagy for their optimal infection during the different stages of life cycle. This review provides a perspective on the emerging evidence that the “positive feedback” between autophagy induction and EVA71 infection, as well as its potential mechanisms. Furthermore, autophagy may be involved in EVA71-induced nervous system impairment through mediating intracranial viral spread and dysregulating host regulator involved self-damage. Autophagy is a promising therapeutic target in EVA71 infection.
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spelling pubmed-77248272020-12-09 Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection Zhang, Chuanjie Li, Yawei Li, Jingfeng Cell Biosci Review Enterovirus A71 (EVA71) infection continues to remain a vital threat to global public health, especially in the Asia–Pacific region. It is one of the most predominant pathogens that cause hand, foot, and mouth disease (HFMD), which occurs mainly in children below 5 years old. Although EVA71 prevalence has decreased sharply in China with the use of vaccines, epidemiological studies still indicate that EVA71 infection involves severe and even fatal HFMD cases. As a result, it remains more fundamental research into the pathogenesis of EVA71 as well as to develop specific anti-viral therapy. Autophagy is a conserved, self-degradation system that is critical for maintaining cellular homeostasis. It involves a variety of biological functions, such as development, cellular differentiation, nutritional starvation, and defense against pathogens. However, accumulating evidence has indicated that EVA71 induces autophagy and hijacks the process of autophagy for their optimal infection during the different stages of life cycle. This review provides a perspective on the emerging evidence that the “positive feedback” between autophagy induction and EVA71 infection, as well as its potential mechanisms. Furthermore, autophagy may be involved in EVA71-induced nervous system impairment through mediating intracranial viral spread and dysregulating host regulator involved self-damage. Autophagy is a promising therapeutic target in EVA71 infection. BioMed Central 2020-12-09 /pmc/articles/PMC7724827/ /pubmed/33298183 http://dx.doi.org/10.1186/s13578-020-00503-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Chuanjie
Li, Yawei
Li, Jingfeng
Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection
title Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection
title_full Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection
title_fullStr Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection
title_full_unstemmed Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection
title_short Dysregulated autophagy contributes to the pathogenesis of enterovirus A71 infection
title_sort dysregulated autophagy contributes to the pathogenesis of enterovirus a71 infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7724827/
https://www.ncbi.nlm.nih.gov/pubmed/33298183
http://dx.doi.org/10.1186/s13578-020-00503-2
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