FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein

In this issue of Cell Host & Microbe, Lu et al. utilize single-molecule FRET to reveal the conformation dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, showing transitions from a closed ground state to the open receptor-accessible conformation via an o...

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Autores principales: Serrão, Vitor Hugo B., Lee, Jeffrey E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725053/
https://www.ncbi.nlm.nih.gov/pubmed/33301717
http://dx.doi.org/10.1016/j.chom.2020.11.008
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author Serrão, Vitor Hugo B.
Lee, Jeffrey E.
author_facet Serrão, Vitor Hugo B.
Lee, Jeffrey E.
author_sort Serrão, Vitor Hugo B.
collection PubMed
description In this issue of Cell Host & Microbe, Lu et al. utilize single-molecule FRET to reveal the conformation dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, showing transitions from a closed ground state to the open receptor-accessible conformation via an on-path intermediate. These insights into spike conformations will facilitate rational immunogen design.
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spelling pubmed-77250532020-12-10 FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein Serrão, Vitor Hugo B. Lee, Jeffrey E. Cell Host Microbe Preview In this issue of Cell Host & Microbe, Lu et al. utilize single-molecule FRET to reveal the conformation dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, showing transitions from a closed ground state to the open receptor-accessible conformation via an on-path intermediate. These insights into spike conformations will facilitate rational immunogen design. Elsevier Inc. 2020-12-09 2020-12-09 /pmc/articles/PMC7725053/ /pubmed/33301717 http://dx.doi.org/10.1016/j.chom.2020.11.008 Text en © 2020 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Preview
Serrão, Vitor Hugo B.
Lee, Jeffrey E.
FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
title FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
title_full FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
title_fullStr FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
title_full_unstemmed FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
title_short FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein
title_sort freting over sars-cov-2: conformational dynamics of the spike glycoprotein
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725053/
https://www.ncbi.nlm.nih.gov/pubmed/33301717
http://dx.doi.org/10.1016/j.chom.2020.11.008
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