Structure of human GABA(B) receptor in an inactive state

Human GABA(B) G protein-coupled receptor (GPCR), a member of the class C family, mediates inhibitory neurotransmission and is implicated in epilepsy, pain, and addiction(1). A unique GPCR known to require heterodimerization for function(2–6), its two subunits, GABA(B1) and GABA(B2), are structurally...

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Detalles Bibliográficos
Autores principales: Park, Jinseo, Fu, Ziao, Frangaj, Aurel, Liu, Jonathan, Mosyak, Lidia, Shen, Tong, Slavkovich, Vesna N., Ray, Kimberly M., Taura, Jaume, Cao, Baohua, Geng, Yong, Zuo, Hao, Kou, Yongjun, Grassucci, Robert, Chen, Shaoxia, Liu, Zheng, Lin, Xin, Williams, Justin P., Rice, William J., Eng, Edward T., Huang, Rick K., Soni, Rajesh K., Kloss, Brian, Yu, Zhiheng, Javitch, Jonathan A., Hendrickson, Wayne A., Slesinger, Paul A., Quick, Matthias, Graziano, Joseph, Yu, Hongtao, Fiehn, Oliver, Clarke, Oliver B., Frank, Joachim, Fan, Qing R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725281/
https://www.ncbi.nlm.nih.gov/pubmed/32581365
http://dx.doi.org/10.1038/s41586-020-2452-0

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