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In silico prediction of ARB resistance: A first step in creating personalized ARB therapy
Angiotensin II type 1 receptor (AT(1)R) blockers (ARBs) are among the most prescribed drugs. However, ARB effectiveness varies widely, which may be due to non-synonymous single nucleotide polymorphisms (nsSNPs) within the AT(1)R gene. The AT(1)R coding sequence contains over 100 nsSNPs; therefore, t...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725353/ https://www.ncbi.nlm.nih.gov/pubmed/33237899 http://dx.doi.org/10.1371/journal.pcbi.1007719 |