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The local stability of a modified multi-strain SIR model for emerging viral strains
We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the population when a preexisting strain has reached equilbrium. We assume that this newer strain does not exhibit cross-immunity with the original strain, hence those who are...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725381/ https://www.ncbi.nlm.nih.gov/pubmed/33296417 http://dx.doi.org/10.1371/journal.pone.0243408 |
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author | Fudolig, Miguel Howard, Reka |
author_facet | Fudolig, Miguel Howard, Reka |
author_sort | Fudolig, Miguel |
collection | PubMed |
description | We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the population when a preexisting strain has reached equilbrium. We assume that this newer strain does not exhibit cross-immunity with the original strain, hence those who are vaccinated and recovered from the original strain become susceptible to the newer strain. Recent events involving the COVID-19 virus shows that it is possible for a viral strain to emerge from a population at a time when the influenza virus, a well-known virus with a vaccine readily available, is active in a population. We solved for four different equilibrium points and investigated the conditions for existence and local stability. The reproduction number was also determined for the epidemiological model and found to be consistent with the local stability condition for the disease-free equilibrium. |
format | Online Article Text |
id | pubmed-7725381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77253812020-12-16 The local stability of a modified multi-strain SIR model for emerging viral strains Fudolig, Miguel Howard, Reka PLoS One Research Article We study a novel multi-strain SIR epidemic model with selective immunity by vaccination. A newer strain is made to emerge in the population when a preexisting strain has reached equilbrium. We assume that this newer strain does not exhibit cross-immunity with the original strain, hence those who are vaccinated and recovered from the original strain become susceptible to the newer strain. Recent events involving the COVID-19 virus shows that it is possible for a viral strain to emerge from a population at a time when the influenza virus, a well-known virus with a vaccine readily available, is active in a population. We solved for four different equilibrium points and investigated the conditions for existence and local stability. The reproduction number was also determined for the epidemiological model and found to be consistent with the local stability condition for the disease-free equilibrium. Public Library of Science 2020-12-09 /pmc/articles/PMC7725381/ /pubmed/33296417 http://dx.doi.org/10.1371/journal.pone.0243408 Text en © 2020 Fudolig, Howard http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Fudolig, Miguel Howard, Reka The local stability of a modified multi-strain SIR model for emerging viral strains |
title | The local stability of a modified multi-strain SIR model for emerging viral strains |
title_full | The local stability of a modified multi-strain SIR model for emerging viral strains |
title_fullStr | The local stability of a modified multi-strain SIR model for emerging viral strains |
title_full_unstemmed | The local stability of a modified multi-strain SIR model for emerging viral strains |
title_short | The local stability of a modified multi-strain SIR model for emerging viral strains |
title_sort | local stability of a modified multi-strain sir model for emerging viral strains |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725381/ https://www.ncbi.nlm.nih.gov/pubmed/33296417 http://dx.doi.org/10.1371/journal.pone.0243408 |
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