DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension

DNA methylation plays critical roles in vascular pathology of pulmonary hypertension (PH). The underlying mechanism, however, remains undetermined. Here, we demonstrate that global DNA methylation was elevated in the lungs of PH rat models after monocrotaline administration or hypobaric hypoxia expo...

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Detalles Bibliográficos
Autores principales: Yan, Yi, He, Yang-Yang, Jiang, Xin, Wang, Yong, Chen, Ji-Wang, Zhao, Jun-Han, Ye, Jue, Lian, Tian-Yu, Zhang, Xu, Zhang, Ru-Jiao, Lu, Dan, Guo, Shan-Shan, Xu, Xi-Qi, Sun, Kai, Li, Su-Qi, Zhang, Lian-Feng, Zhang, Xue, Zhang, Shu-Yang, Jing, Zhi-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725449/
https://www.ncbi.nlm.nih.gov/pubmed/33298433
http://dx.doi.org/10.1126/sciadv.aba2470

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