Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2. Here, the cryo-EM structure of PRC2 on dinucleosomes reveals how binding of its catalytic su...

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Detalles Bibliográficos
Autores principales: Finogenova, Ksenia, Bonnet, Jacques, Poepsel, Simon, Schäfer, Ingmar B, Finkl, Katja, Schmid, Katharina, Litz, Claudia, Strauss, Mike, Benda, Christian, Müller, Jürg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725500/
https://www.ncbi.nlm.nih.gov/pubmed/33211010
http://dx.doi.org/10.7554/eLife.61964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725500/
https://www.ncbi.nlm.nih.gov/pubmed/33211010
http://dx.doi.org/10.7554/eLife.61964

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