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Recent Research on Methods to Improve Tumor Hypoxia Environment

Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However...

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Autores principales: Zhu, Xiao-Hua, Du, Jun-Xi, Zhu, Dan, Ren, Shen-Zhen, Chen, Kun, Zhu, Hai-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725563/
https://www.ncbi.nlm.nih.gov/pubmed/33343807
http://dx.doi.org/10.1155/2020/5721258
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author Zhu, Xiao-Hua
Du, Jun-Xi
Zhu, Dan
Ren, Shen-Zhen
Chen, Kun
Zhu, Hai-Liang
author_facet Zhu, Xiao-Hua
Du, Jun-Xi
Zhu, Dan
Ren, Shen-Zhen
Chen, Kun
Zhu, Hai-Liang
author_sort Zhu, Xiao-Hua
collection PubMed
description Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However, due to insufficient blood flow and oxygen (O(2)) supply in solid tumors, hypoxia is caused, leading to decreased sensitivity of tumor cells and poor therapeutic effects. In addition, hypoxia will also lead to resistance to most anticancer drugs, accelerate malignant progress, and increase metastasis. In solid tumors, adequate O(2) supply and adequate delivery of anticancer drugs are essential to improve radiotherapy and chemotherapy sensitivity. In recent decades, the researches on relieving tumor hypoxia have attracted researchers' extensive attention and achieved good results. However, as far as we know, there is no detailed review of the researches on alleviating tumor hypoxia. Therefore, in this contribution, we hope to give an overview of the researches on methods to improve tumor hypoxia environment and summarize their effect and application in tumor therapy, to provide a methodological reference for the research and development of new antitumor agents.
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spelling pubmed-77255632020-12-17 Recent Research on Methods to Improve Tumor Hypoxia Environment Zhu, Xiao-Hua Du, Jun-Xi Zhu, Dan Ren, Shen-Zhen Chen, Kun Zhu, Hai-Liang Oxid Med Cell Longev Review Article Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However, due to insufficient blood flow and oxygen (O(2)) supply in solid tumors, hypoxia is caused, leading to decreased sensitivity of tumor cells and poor therapeutic effects. In addition, hypoxia will also lead to resistance to most anticancer drugs, accelerate malignant progress, and increase metastasis. In solid tumors, adequate O(2) supply and adequate delivery of anticancer drugs are essential to improve radiotherapy and chemotherapy sensitivity. In recent decades, the researches on relieving tumor hypoxia have attracted researchers' extensive attention and achieved good results. However, as far as we know, there is no detailed review of the researches on alleviating tumor hypoxia. Therefore, in this contribution, we hope to give an overview of the researches on methods to improve tumor hypoxia environment and summarize their effect and application in tumor therapy, to provide a methodological reference for the research and development of new antitumor agents. Hindawi 2020-12-02 /pmc/articles/PMC7725563/ /pubmed/33343807 http://dx.doi.org/10.1155/2020/5721258 Text en Copyright © 2020 Xiao-Hua Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhu, Xiao-Hua
Du, Jun-Xi
Zhu, Dan
Ren, Shen-Zhen
Chen, Kun
Zhu, Hai-Liang
Recent Research on Methods to Improve Tumor Hypoxia Environment
title Recent Research on Methods to Improve Tumor Hypoxia Environment
title_full Recent Research on Methods to Improve Tumor Hypoxia Environment
title_fullStr Recent Research on Methods to Improve Tumor Hypoxia Environment
title_full_unstemmed Recent Research on Methods to Improve Tumor Hypoxia Environment
title_short Recent Research on Methods to Improve Tumor Hypoxia Environment
title_sort recent research on methods to improve tumor hypoxia environment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725563/
https://www.ncbi.nlm.nih.gov/pubmed/33343807
http://dx.doi.org/10.1155/2020/5721258
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