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Recent Research on Methods to Improve Tumor Hypoxia Environment
Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725563/ https://www.ncbi.nlm.nih.gov/pubmed/33343807 http://dx.doi.org/10.1155/2020/5721258 |
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author | Zhu, Xiao-Hua Du, Jun-Xi Zhu, Dan Ren, Shen-Zhen Chen, Kun Zhu, Hai-Liang |
author_facet | Zhu, Xiao-Hua Du, Jun-Xi Zhu, Dan Ren, Shen-Zhen Chen, Kun Zhu, Hai-Liang |
author_sort | Zhu, Xiao-Hua |
collection | PubMed |
description | Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However, due to insufficient blood flow and oxygen (O(2)) supply in solid tumors, hypoxia is caused, leading to decreased sensitivity of tumor cells and poor therapeutic effects. In addition, hypoxia will also lead to resistance to most anticancer drugs, accelerate malignant progress, and increase metastasis. In solid tumors, adequate O(2) supply and adequate delivery of anticancer drugs are essential to improve radiotherapy and chemotherapy sensitivity. In recent decades, the researches on relieving tumor hypoxia have attracted researchers' extensive attention and achieved good results. However, as far as we know, there is no detailed review of the researches on alleviating tumor hypoxia. Therefore, in this contribution, we hope to give an overview of the researches on methods to improve tumor hypoxia environment and summarize their effect and application in tumor therapy, to provide a methodological reference for the research and development of new antitumor agents. |
format | Online Article Text |
id | pubmed-7725563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-77255632020-12-17 Recent Research on Methods to Improve Tumor Hypoxia Environment Zhu, Xiao-Hua Du, Jun-Xi Zhu, Dan Ren, Shen-Zhen Chen, Kun Zhu, Hai-Liang Oxid Med Cell Longev Review Article Cancer is a major disease burden worldwide. In recent years, in addition to surgical resection, radiotherapy and chemotherapy are recognized as the most effective methods for treating solid tumors. These methods have been introduced to treat tumors of different origins and stages clinically. However, due to insufficient blood flow and oxygen (O(2)) supply in solid tumors, hypoxia is caused, leading to decreased sensitivity of tumor cells and poor therapeutic effects. In addition, hypoxia will also lead to resistance to most anticancer drugs, accelerate malignant progress, and increase metastasis. In solid tumors, adequate O(2) supply and adequate delivery of anticancer drugs are essential to improve radiotherapy and chemotherapy sensitivity. In recent decades, the researches on relieving tumor hypoxia have attracted researchers' extensive attention and achieved good results. However, as far as we know, there is no detailed review of the researches on alleviating tumor hypoxia. Therefore, in this contribution, we hope to give an overview of the researches on methods to improve tumor hypoxia environment and summarize their effect and application in tumor therapy, to provide a methodological reference for the research and development of new antitumor agents. Hindawi 2020-12-02 /pmc/articles/PMC7725563/ /pubmed/33343807 http://dx.doi.org/10.1155/2020/5721258 Text en Copyright © 2020 Xiao-Hua Zhu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhu, Xiao-Hua Du, Jun-Xi Zhu, Dan Ren, Shen-Zhen Chen, Kun Zhu, Hai-Liang Recent Research on Methods to Improve Tumor Hypoxia Environment |
title | Recent Research on Methods to Improve Tumor Hypoxia Environment |
title_full | Recent Research on Methods to Improve Tumor Hypoxia Environment |
title_fullStr | Recent Research on Methods to Improve Tumor Hypoxia Environment |
title_full_unstemmed | Recent Research on Methods to Improve Tumor Hypoxia Environment |
title_short | Recent Research on Methods to Improve Tumor Hypoxia Environment |
title_sort | recent research on methods to improve tumor hypoxia environment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725563/ https://www.ncbi.nlm.nih.gov/pubmed/33343807 http://dx.doi.org/10.1155/2020/5721258 |
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