Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report

A 73-year-old woman was admitted to our hospital for treatment of vomiting. Four months previously, she had been diagnosed with lung adenocarcinoma (cT3N3M1a stage IVA) and started receiving afatinib as first-line treatment. On admission, the primary tumor had shrunk, but abdominal computed tomograp...

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Autores principales: Ota, Hiroki, Ota, Tomohiro, Narisawa, Eriko, Chiba, Hideyuki, Nakayama, Hiroshi, Tsukumo, Yoko, Sakamoto, Atsuhiko, Honma, Naoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725614/
https://www.ncbi.nlm.nih.gov/pubmed/32727983
http://dx.doi.org/10.2169/internalmedicine.4869-20
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author Ota, Hiroki
Ota, Tomohiro
Narisawa, Eriko
Chiba, Hideyuki
Nakayama, Hiroshi
Tsukumo, Yoko
Sakamoto, Atsuhiko
Honma, Naoko
author_facet Ota, Hiroki
Ota, Tomohiro
Narisawa, Eriko
Chiba, Hideyuki
Nakayama, Hiroshi
Tsukumo, Yoko
Sakamoto, Atsuhiko
Honma, Naoko
author_sort Ota, Hiroki
collection PubMed
description A 73-year-old woman was admitted to our hospital for treatment of vomiting. Four months previously, she had been diagnosed with lung adenocarcinoma (cT3N3M1a stage IVA) and started receiving afatinib as first-line treatment. On admission, the primary tumor had shrunk, but abdominal computed tomography revealed a new retroperitoneal lesion causing duodenal obstruction and hydronephrosis. She underwent gastrojejunostomy, and a biopsy of the peritoneum revealed adenocarcinoma. She was treated with second-line chemotherapy but developed cerebral infarction and died 104 days after admission. An autopsy revealed marked fibrosis with scattered tumor cells in the retroperitoneum. The underlying mechanism of the metastasis is discussed.
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spelling pubmed-77256142020-12-21 Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report Ota, Hiroki Ota, Tomohiro Narisawa, Eriko Chiba, Hideyuki Nakayama, Hiroshi Tsukumo, Yoko Sakamoto, Atsuhiko Honma, Naoko Intern Med Case Report A 73-year-old woman was admitted to our hospital for treatment of vomiting. Four months previously, she had been diagnosed with lung adenocarcinoma (cT3N3M1a stage IVA) and started receiving afatinib as first-line treatment. On admission, the primary tumor had shrunk, but abdominal computed tomography revealed a new retroperitoneal lesion causing duodenal obstruction and hydronephrosis. She underwent gastrojejunostomy, and a biopsy of the peritoneum revealed adenocarcinoma. She was treated with second-line chemotherapy but developed cerebral infarction and died 104 days after admission. An autopsy revealed marked fibrosis with scattered tumor cells in the retroperitoneum. The underlying mechanism of the metastasis is discussed. The Japanese Society of Internal Medicine 2020-07-28 2020-11-15 /pmc/articles/PMC7725614/ /pubmed/32727983 http://dx.doi.org/10.2169/internalmedicine.4869-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ota, Hiroki
Ota, Tomohiro
Narisawa, Eriko
Chiba, Hideyuki
Nakayama, Hiroshi
Tsukumo, Yoko
Sakamoto, Atsuhiko
Honma, Naoko
Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report
title Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report
title_full Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report
title_fullStr Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report
title_full_unstemmed Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report
title_short Retroperitoneal Metastasis, with Marked Fibrosis, of Lung Adenocarcinoma after Afatinib Treatment: An Autopsy Case Report
title_sort retroperitoneal metastasis, with marked fibrosis, of lung adenocarcinoma after afatinib treatment: an autopsy case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725614/
https://www.ncbi.nlm.nih.gov/pubmed/32727983
http://dx.doi.org/10.2169/internalmedicine.4869-20
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