A Favipiravir-induced Fever in a Patient with COVID-19

We herein report the first case of a fever induced by favipiravir, a potential coronavirus disease 2019 therapeutic drug. An 82-year-old man diagnosed with bilateral pneumonia was transferred to our hospital following a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reacti...

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Autores principales: Kurita, Takashi, Ishida, Keiko, Muranaka, Emiri, Sasazawa, Hiroki, Mito, Haruki, Yano, Yudai, Hase, Ryota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725626/
https://www.ncbi.nlm.nih.gov/pubmed/33191372
http://dx.doi.org/10.2169/internalmedicine.5394-20
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author Kurita, Takashi
Ishida, Keiko
Muranaka, Emiri
Sasazawa, Hiroki
Mito, Haruki
Yano, Yudai
Hase, Ryota
author_facet Kurita, Takashi
Ishida, Keiko
Muranaka, Emiri
Sasazawa, Hiroki
Mito, Haruki
Yano, Yudai
Hase, Ryota
author_sort Kurita, Takashi
collection PubMed
description We herein report the first case of a fever induced by favipiravir, a potential coronavirus disease 2019 therapeutic drug. An 82-year-old man diagnosed with bilateral pneumonia was transferred to our hospital following a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test. He was treated with compassionate use of favipiravir. Both his oxygen demand and fever gradually improved after admission; however, his fever relapsed, and the C-reactive protein (CRP) levels increased on day 7. We diagnosed his fever as being favipiravir-induced. The fever resolved a few days after favipiravir discontinuation, demonstrating the accuracy of the diagnosis. This case revealed that favipiravir can induce a fever.
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spelling pubmed-77256262020-12-21 A Favipiravir-induced Fever in a Patient with COVID-19 Kurita, Takashi Ishida, Keiko Muranaka, Emiri Sasazawa, Hiroki Mito, Haruki Yano, Yudai Hase, Ryota Intern Med Case Report We herein report the first case of a fever induced by favipiravir, a potential coronavirus disease 2019 therapeutic drug. An 82-year-old man diagnosed with bilateral pneumonia was transferred to our hospital following a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test. He was treated with compassionate use of favipiravir. Both his oxygen demand and fever gradually improved after admission; however, his fever relapsed, and the C-reactive protein (CRP) levels increased on day 7. We diagnosed his fever as being favipiravir-induced. The fever resolved a few days after favipiravir discontinuation, demonstrating the accuracy of the diagnosis. This case revealed that favipiravir can induce a fever. The Japanese Society of Internal Medicine 2020-11-15 /pmc/articles/PMC7725626/ /pubmed/33191372 http://dx.doi.org/10.2169/internalmedicine.5394-20 Text en Copyright © 2020 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Kurita, Takashi
Ishida, Keiko
Muranaka, Emiri
Sasazawa, Hiroki
Mito, Haruki
Yano, Yudai
Hase, Ryota
A Favipiravir-induced Fever in a Patient with COVID-19
title A Favipiravir-induced Fever in a Patient with COVID-19
title_full A Favipiravir-induced Fever in a Patient with COVID-19
title_fullStr A Favipiravir-induced Fever in a Patient with COVID-19
title_full_unstemmed A Favipiravir-induced Fever in a Patient with COVID-19
title_short A Favipiravir-induced Fever in a Patient with COVID-19
title_sort favipiravir-induced fever in a patient with covid-19
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725626/
https://www.ncbi.nlm.nih.gov/pubmed/33191372
http://dx.doi.org/10.2169/internalmedicine.5394-20
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