Pathologically Proven Gadolinium-enhanced MRI Lesions in the Bilateral Corticospinal Tracts in Lymphomatosis Cerebri

A 78-year-old woman in complete remission of mass-forming primary central nervous system lymphoma (PCNSL) showed diffuse leukoencephalopathy as well as corticospinal tract lesions with intense gadolinium enhancement on magnetic resonance imaging (MRI). She died 3 months later. In line with the MRI f...

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Detalles Bibliográficos
Autores principales: Yamaura, Genpei, Ogasawara, Akihiro, Ito, Takeshi, Ohsugi, Shizuka, Kanatsuka, Yoichi, Hayashi, Ryuichiro, Iwashita, Hiromichi, Hayashi, Hiroyuki, Koyano, Shigeru, Yamaguchi, Shigeki, Tanaka, Fumiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725641/
https://www.ncbi.nlm.nih.gov/pubmed/32713909
http://dx.doi.org/10.2169/internalmedicine.4382-19
Descripción
Sumario:A 78-year-old woman in complete remission of mass-forming primary central nervous system lymphoma (PCNSL) showed diffuse leukoencephalopathy as well as corticospinal tract lesions with intense gadolinium enhancement on magnetic resonance imaging (MRI). She died 3 months later. In line with the MRI findings, pathological examination revealed dense infiltration of atypical lymphoid cells, consistent with a diagnosis of lymphomatosis cerebri (LC)-type PCNSL. This is the first report of LC in which the corticospinal tracts demonstrated robust contrast enhancement directly corresponding to the neuropathological findings, and it is also a rare instance in which LC presented as a recurrence of typical PCNSL.

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