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Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis

Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-rel...

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Autores principales: Hu, Rui-ting, Yu, Qian, Zhou, Shao-dan, Yin, Yi-xin, Hu, Rui-guang, Lu, Hai-peng, Hu, Bang-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725685/
https://www.ncbi.nlm.nih.gov/pubmed/33324198
http://dx.doi.org/10.3389/fnagi.2020.605961
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author Hu, Rui-ting
Yu, Qian
Zhou, Shao-dan
Yin, Yi-xin
Hu, Rui-guang
Lu, Hai-peng
Hu, Bang-li
author_facet Hu, Rui-ting
Yu, Qian
Zhou, Shao-dan
Yin, Yi-xin
Hu, Rui-guang
Lu, Hai-peng
Hu, Bang-li
author_sort Hu, Rui-ting
collection PubMed
description Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened. The hub genes of the network were identified and validated by an independent cohort. The functional pathways of hub genes were analyzed. Results: The co-expression network revealed a module that related to the AD status, and 101 status-related genes were screened from the trait-related module. Gene enrichment analysis indicated that these status-related genes are involved in synaptic processes and pathways. Four hub genes (ENO2, ELAVL4, SNAP91, and NEFM) were identified from the module, and these hub genes all participated in AD-related pathways, but the associations of each gene with clinical features were variable. An independent dataset confirmed the different expression of hub genes between AD and controls. Conclusions: Four novel genes associated with AD pathogenesis were identified and validated, which provided novel therapeutic targets for AD.
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spelling pubmed-77256852020-12-14 Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis Hu, Rui-ting Yu, Qian Zhou, Shao-dan Yin, Yi-xin Hu, Rui-guang Lu, Hai-peng Hu, Bang-li Front Aging Neurosci Neuroscience Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened. The hub genes of the network were identified and validated by an independent cohort. The functional pathways of hub genes were analyzed. Results: The co-expression network revealed a module that related to the AD status, and 101 status-related genes were screened from the trait-related module. Gene enrichment analysis indicated that these status-related genes are involved in synaptic processes and pathways. Four hub genes (ENO2, ELAVL4, SNAP91, and NEFM) were identified from the module, and these hub genes all participated in AD-related pathways, but the associations of each gene with clinical features were variable. An independent dataset confirmed the different expression of hub genes between AD and controls. Conclusions: Four novel genes associated with AD pathogenesis were identified and validated, which provided novel therapeutic targets for AD. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7725685/ /pubmed/33324198 http://dx.doi.org/10.3389/fnagi.2020.605961 Text en Copyright © 2020 Hu, Yu, Zhou, Yin, Hu, Lu and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hu, Rui-ting
Yu, Qian
Zhou, Shao-dan
Yin, Yi-xin
Hu, Rui-guang
Lu, Hai-peng
Hu, Bang-li
Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
title Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
title_full Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
title_fullStr Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
title_full_unstemmed Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
title_short Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
title_sort co-expression network analysis reveals novel genes underlying alzheimer’s disease pathogenesis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725685/
https://www.ncbi.nlm.nih.gov/pubmed/33324198
http://dx.doi.org/10.3389/fnagi.2020.605961
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