Cargando…
Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-rel...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725685/ https://www.ncbi.nlm.nih.gov/pubmed/33324198 http://dx.doi.org/10.3389/fnagi.2020.605961 |
_version_ | 1783620750521925632 |
---|---|
author | Hu, Rui-ting Yu, Qian Zhou, Shao-dan Yin, Yi-xin Hu, Rui-guang Lu, Hai-peng Hu, Bang-li |
author_facet | Hu, Rui-ting Yu, Qian Zhou, Shao-dan Yin, Yi-xin Hu, Rui-guang Lu, Hai-peng Hu, Bang-li |
author_sort | Hu, Rui-ting |
collection | PubMed |
description | Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened. The hub genes of the network were identified and validated by an independent cohort. The functional pathways of hub genes were analyzed. Results: The co-expression network revealed a module that related to the AD status, and 101 status-related genes were screened from the trait-related module. Gene enrichment analysis indicated that these status-related genes are involved in synaptic processes and pathways. Four hub genes (ENO2, ELAVL4, SNAP91, and NEFM) were identified from the module, and these hub genes all participated in AD-related pathways, but the associations of each gene with clinical features were variable. An independent dataset confirmed the different expression of hub genes between AD and controls. Conclusions: Four novel genes associated with AD pathogenesis were identified and validated, which provided novel therapeutic targets for AD. |
format | Online Article Text |
id | pubmed-7725685 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77256852020-12-14 Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis Hu, Rui-ting Yu, Qian Zhou, Shao-dan Yin, Yi-xin Hu, Rui-guang Lu, Hai-peng Hu, Bang-li Front Aging Neurosci Neuroscience Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways. Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened. The hub genes of the network were identified and validated by an independent cohort. The functional pathways of hub genes were analyzed. Results: The co-expression network revealed a module that related to the AD status, and 101 status-related genes were screened from the trait-related module. Gene enrichment analysis indicated that these status-related genes are involved in synaptic processes and pathways. Four hub genes (ENO2, ELAVL4, SNAP91, and NEFM) were identified from the module, and these hub genes all participated in AD-related pathways, but the associations of each gene with clinical features were variable. An independent dataset confirmed the different expression of hub genes between AD and controls. Conclusions: Four novel genes associated with AD pathogenesis were identified and validated, which provided novel therapeutic targets for AD. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7725685/ /pubmed/33324198 http://dx.doi.org/10.3389/fnagi.2020.605961 Text en Copyright © 2020 Hu, Yu, Zhou, Yin, Hu, Lu and Hu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Hu, Rui-ting Yu, Qian Zhou, Shao-dan Yin, Yi-xin Hu, Rui-guang Lu, Hai-peng Hu, Bang-li Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis |
title | Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis |
title_full | Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis |
title_fullStr | Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis |
title_full_unstemmed | Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis |
title_short | Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis |
title_sort | co-expression network analysis reveals novel genes underlying alzheimer’s disease pathogenesis |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725685/ https://www.ncbi.nlm.nih.gov/pubmed/33324198 http://dx.doi.org/10.3389/fnagi.2020.605961 |
work_keys_str_mv | AT huruiting coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis AT yuqian coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis AT zhoushaodan coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis AT yinyixin coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis AT huruiguang coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis AT luhaipeng coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis AT hubangli coexpressionnetworkanalysisrevealsnovelgenesunderlyingalzheimersdiseasepathogenesis |