TGFβ-blockade uncovers stromal plasticity in tumors by revealing the existence of a subset of interferon-licensed fibroblasts

Despite the increasing interest in targeting stromal elements of the tumor microenvironment, we still face tremendous challenges in developing adequate therapeutics to modify the tumor stromal landscape. A major obstacle to this is our poor understanding of the phenotypic and functional heterogeneit...

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Detalles Bibliográficos
Autores principales: Grauel, Angelo L., Nguyen, Beverly, Ruddy, David, Laszewski, Tyler, Schwartz, Stephanie, Chang, Jonathan, Chen, Julie, Piquet, Michelle, Pelletier, Marc, Yan, Zheng, Kirkpatrick, Nathaniel D., Wu, Jincheng, deWeck, Antoine, Riester, Markus, Hims, Matt, Geyer, Felipe Correa, Wagner, Joel, MacIsaac, Kenzie, Deeds, James, Diwanji, Rohan, Jayaraman, Pushpa, Yu, Yenyen, Simmons, Quincey, Weng, Shaobu, Raza, Alina, Minie, Brian, Dostalek, Mirek, Chikkegowda, Pavitra, Ruda, Vera, Iartchouk, Oleg, Chen, Naiyan, Thierry, Raphael, Zhou, Joseph, Pruteanu-Malinici, Iulian, Fabre, Claire, Engelman, Jeffrey A., Dranoff, Glenn, Cremasco, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725805/
https://www.ncbi.nlm.nih.gov/pubmed/33298926
http://dx.doi.org/10.1038/s41467-020-19920-5

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