Global genetic deletion of Ca(V)3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers

We previously documented that the Ca(V)3.3 isoform of T-type calcium channels (T-channels) is inhibited by clinically relevant concentrations of volatile anaesthetics, including isoflurane. However, little is understood about the functional role of Ca(V)3.3 channels in anaesthetic-induced hypnosis a...

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Detalles Bibliográficos
Autores principales: Feseha, Simon, Timic Stamenic, Tamara, Wallace, Damon, Tamag, Caesare, Yang, Lingling, Pan, Jen Q., Todorovic, Slobodan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725806/
https://www.ncbi.nlm.nih.gov/pubmed/33299036
http://dx.doi.org/10.1038/s41598-020-78488-8

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