Heme biosynthesis depends on previously unrecognized acquisition of iron-sulfur cofactors in human amino-levulinic acid dehydratase

Heme biosynthesis and iron-sulfur cluster (ISC) biogenesis are two major mammalian metabolic pathways that require iron. It has long been known that these two pathways interconnect, but the previously described interactions do not fully explain why heme biosynthesis depends on intact ISC biogenesis....

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Detalles Bibliográficos
Autores principales: Liu, Gang, Sil, Debangsu, Maio, Nunziata, Tong, Wing-Hang, Bollinger, J. Martin, Krebs, Carsten, Rouault, Tracey Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725820/
https://www.ncbi.nlm.nih.gov/pubmed/33298951
http://dx.doi.org/10.1038/s41467-020-20145-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725820/
https://www.ncbi.nlm.nih.gov/pubmed/33298951
http://dx.doi.org/10.1038/s41467-020-20145-9

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