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Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents

We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly sug...

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Autores principales: Moorhouse, Frederik Jan, Cornell, Sonia, Gerstl, Lucia, Tacke, Moritz, Roser, Timo, Heinen, Florian, Bonfert, Michaela, von Stülpnagel, Celina, Wagner, Matias, Borggraefe, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725836/
https://www.ncbi.nlm.nih.gov/pubmed/33298990
http://dx.doi.org/10.1038/s41598-020-78218-0
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author Moorhouse, Frederik Jan
Cornell, Sonia
Gerstl, Lucia
Tacke, Moritz
Roser, Timo
Heinen, Florian
Bonfert, Michaela
von Stülpnagel, Celina
Wagner, Matias
Borggraefe, Ingo
author_facet Moorhouse, Frederik Jan
Cornell, Sonia
Gerstl, Lucia
Tacke, Moritz
Roser, Timo
Heinen, Florian
Bonfert, Michaela
von Stülpnagel, Celina
Wagner, Matias
Borggraefe, Ingo
author_sort Moorhouse, Frederik Jan
collection PubMed
description We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or structural/numeric chromosomal etiology (genetic epilepsies, GE group). Cognitive (total IQ and subcategories) and behavioral parameters (CBCL) were assessed at the tertiary epilepsy center of the University of Munich (Germany). We used ANOVA with post-hoc Bonferroni-correction to explore significant mean differences and Fisher’s exact test for significant proportional differences of intelligence impairment and behavioral problems. 126 (56 IGE/GGE, 26 IFE, 44 GE) patients were available. Total IQ was 89.0 ± 15.9 (95% CI 84.5–93.4) for IGE/GGE, 94.8 ± 18.1 (95% CI 87.3–102.3) for IFE and 76.4 ± 22.4 (95% CI 67.6–85.3) for GE (p = 0.001). The same trend was significant for all but one IQ subcategory. The rate of patients with an intelligence impairment (total IQ < 70) was higher for GE (40%) than for IGE/GGE (14%) and for IFE (7%) patients (p = 0.033). There were no significant differences between groups for behavior scores and behavioral problems. This study shows that the current ILAE classification of epilepsies with genetic etiology creates a heterogeneous group of patients with respect to cognitive performance but not behavior. These findings may help in further delineating epilepsies as regards cognitive performance, notwithstanding their closely related etiological classification.
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spelling pubmed-77258362020-12-14 Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents Moorhouse, Frederik Jan Cornell, Sonia Gerstl, Lucia Tacke, Moritz Roser, Timo Heinen, Florian Bonfert, Michaela von Stülpnagel, Celina Wagner, Matias Borggraefe, Ingo Sci Rep Article We investigated the cognitive and behavioral profile of three distinct groups of epilepsies with a genetic background for intergroup differences: (1) idiopathic/genetic generalized epilepsies (IGE/GGE group); (2) idiopathic focal epilepsies (IFE group); and (3) epilepsies with proven or strongly suggested monogenic or structural/numeric chromosomal etiology (genetic epilepsies, GE group). Cognitive (total IQ and subcategories) and behavioral parameters (CBCL) were assessed at the tertiary epilepsy center of the University of Munich (Germany). We used ANOVA with post-hoc Bonferroni-correction to explore significant mean differences and Fisher’s exact test for significant proportional differences of intelligence impairment and behavioral problems. 126 (56 IGE/GGE, 26 IFE, 44 GE) patients were available. Total IQ was 89.0 ± 15.9 (95% CI 84.5–93.4) for IGE/GGE, 94.8 ± 18.1 (95% CI 87.3–102.3) for IFE and 76.4 ± 22.4 (95% CI 67.6–85.3) for GE (p = 0.001). The same trend was significant for all but one IQ subcategory. The rate of patients with an intelligence impairment (total IQ < 70) was higher for GE (40%) than for IGE/GGE (14%) and for IFE (7%) patients (p = 0.033). There were no significant differences between groups for behavior scores and behavioral problems. This study shows that the current ILAE classification of epilepsies with genetic etiology creates a heterogeneous group of patients with respect to cognitive performance but not behavior. These findings may help in further delineating epilepsies as regards cognitive performance, notwithstanding their closely related etiological classification. Nature Publishing Group UK 2020-12-09 /pmc/articles/PMC7725836/ /pubmed/33298990 http://dx.doi.org/10.1038/s41598-020-78218-0 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Moorhouse, Frederik Jan
Cornell, Sonia
Gerstl, Lucia
Tacke, Moritz
Roser, Timo
Heinen, Florian
Bonfert, Michaela
von Stülpnagel, Celina
Wagner, Matias
Borggraefe, Ingo
Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_full Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_fullStr Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_full_unstemmed Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_short Cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
title_sort cognitive performance and behavior across idiopathic/genetic epilepsies in children and adolescents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7725836/
https://www.ncbi.nlm.nih.gov/pubmed/33298990
http://dx.doi.org/10.1038/s41598-020-78218-0
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