Cargando…

Long-Term Outcomes of a Phase I Study With UV1, a Second Generation Telomerase Based Vaccine, in Patients With Advanced Non-Small Cell Lung Cancer

Human telomerase reverse transcriptase (hTERT) is a target antigen for cancer immunotherapy in patients with non-small cell lung cancer (NSCLC). We have tested a novel hTERT vaccine, UV1, designed to give high population coverage. UV1 is composed of three synthetic long peptides containing multiple...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brunsvig, Paal F., Guren, Tormod Kyrre, Nyakas, Marta, Steinfeldt-Reisse, Claudius H., Rasch, Wenche, Kyte, Jon Amund, Juul, Hedvig Vidarsdotter, Aamdal, Steinar, Gaudernack, Gustav, Inderberg, Else Marit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726017/ https://www.ncbi.nlm.nih.gov/pubmed/33324397 http://dx.doi.org/10.3389/fimmu.2020.572172

Ejemplares similares

Combining a Universal Telomerase Based Cancer Vaccine With Ipilimumab in Patients With Metastatic Melanoma - Five-Year Follow Up of a Phase I/IIa Trial
por: Aamdal, Elin, et al.
Publicado: (2021)

Durable and dynamic hTERT immune responses following vaccination with the long-peptide cancer vaccine UV1: long-term follow-up of three phase I clinical trials
por: Ellingsen, Espen Basmo, et al.
Publicado: (2022)

Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
por: Ellingsen, Espen Basmo, et al.
Publicado: (2022)

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes
por: Suso, Else M. Inderberg, et al.
Publicado: (2011)

Targeting Telomerase with an HLA Class II-Restricted TCR for Cancer Immunotherapy
por: Dillard, Pierre, et al.
Publicado: (2021)

Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy
por: Fr Brunsvig, Paal, et al.
Publicado: (2007)

Widespread CD4+ T-cell reactivity to novel hTERT epitopes following vaccination of cancer patients with a single hTERT peptide GV1001
por: Inderberg-Suso, Else-Marit, et al.
Publicado: (2012)

Therapeutic vaccination against autologous cancer stem cells with mRNA-transfected dendritic cells in patients with glioblastoma
por: Vik-Mo, Einar Osland, et al.
Publicado: (2013)

Prognostic biomarkers for immunotherapy with ipilimumab in metastatic melanoma
por: Nyakas, M., et al.
Publicado: (2019)

High sensitivity assays for docetaxel and paclitaxel in plasma using solid-phase extraction and high-performance liquid chromatography with UV detection
por: Andersen, Anders, et al.
Publicado: (2006)

Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy
por: Mensali, Nadia, et al.
Publicado: (2019)

Correction to: Preclinical assessment of transiently TCR redirected T cells for solid tumour immunotherapy
por: Mensali, Nadia, et al.
Publicado: (2019)

T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth
por: Inderberg, Else M., et al.
Publicado: (2017)

Targeting KRAS mutations with HLA class II-restricted TCRs for the treatment of solid tumors
por: Dillard, Pierre, et al.
Publicado: (2021)

Assessing quality of life in a randomized clinical trial: Correcting for missing data
por: Gunnes, Nina, et al.
Publicado: (2009)

Therapeutic cancer vaccination against telomerase: clinical developments in melanoma
por: Ellingsen, Espen Basmo, et al.
Publicado: (2023)

A TCR-based Chimeric Antigen Receptor
por: Walseng, Even, et al.
Publicado: (2017)

Antigen-delivery through invariant chain (CD74) boosts CD8 and CD4 T cell immunity
por: Mensali, Nadia, et al.
Publicado: (2019)

Health-related quality of life in patients with advanced melanoma treated with ipilimumab: prognostic implications and changes during treatment
por: Aamdal, E., et al.
Publicado: (2022)

Telomerase as a Target for Therapeutic Cancer Vaccines and Considerations for Optimizing Their Clinical Potential
por: Ellingsen, Espen Basmo, et al.
Publicado: (2021)

Peptide vaccine targeting mutated GNAS: a potential novel treatment for pseudomyxoma peritonei
por: Flatmark, Kjersti, et al.
Publicado: (2021)

NK cells specifically TCR-dressed to kill cancer cells
por: Mensali, Nadia, et al.
Publicado: (2019)

Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine
por: Sioud, Mouldy, et al.
Publicado: (2016)

Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues
por: Sæbøe-Larssen, Stein, et al.
Publicado: (2006)

Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients
por: Mu, L J, et al.
Publicado: (2005)

Health-Related Quality of Life in Colorectal Cancer Patients Treated With Liver Transplantation Compared to Chemotherapy
por: Smedman, Tor Magnus, et al.
Publicado: (2022)

Sympathetic improvement of cancer vaccine efficacy
por: Inderberg, Else Marit, et al.
Publicado: (2020)

Long-term surviving cancer patients as a source of therapeutic TCR
por: Inderberg, Else Marit, et al.
Publicado: (2020)

Emerging Biomarkers for Immunotherapy in Glioblastoma
por: Mensali, Nadia, et al.
Publicado: (2022)

Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin
por: Andersson, Y, et al.
Publicado: (2015)

Strategies for Improving the Efficacy of CAR T Cells in Solid Cancers
por: Kyte, Jon Amund
Publicado: (2022)

A phase I/II escalation trial design T-RAD: Treatment of metastatic lung cancer with mRNA-engineered T cells expressing a T cell receptor targeting human telomerase reverse transcriptase (hTERT)
por: Maggadóttir, Sólrún Melkorka, et al.
Publicado: (2022)

Determination of CAR T cell metabolism in an optimized protocol
por: Joaquina, Sandy, et al.
Publicado: (2023)

Identification and Characterization of Cells with Cancer Stem Cell Properties in Human Primary Lung Cancer Cell Lines
por: Wang, Ping, et al.
Publicado: (2013)

Telomerase peptide vaccination of patients with non-resectable pancreatic cancer: a dose escalating phase I/II study
por: Bernhardt, S L, et al.
Publicado: (2006)

Chimeric antigen receptor preparation from hybridoma to T-cell expression
por: Köksal, Hakan, et al.
Publicado: (2019)

Circulating Tumor Cell Persistence Associates with Long-Term Clinical Outcome to a Therapeutic Cancer Vaccine in Prostate Cancer
por: Guldvik, Ingrid Jenny, et al.
Publicado: (2021)

P611: CD37 AS A MOLECULAR TARGET FOR CAR-T CELLS AGAINST CHRONIC LYMPHOCYTIC LEUKEMIA
por: Kusowska, Aleksandra, et al.
Publicado: (2023)

Posttransplantation Lymphoproliferative Disease Treated by Retransplantation
por: Weum Abrahamsen, Ingerid, et al.
Publicado: (2020)

The internal structure of foster-parent completed SDQ for school-aged children
por: Lehmann, Stine, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hr1u2rjrmfj68j5cgc430jp1ce