Application of the PET ligand [(11)C]ORM-13070 to examine receptor occupancy by the α(2C)-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

BACKGROUND: Availability of the α(2C)-adrenoceptor (α(2C)-AR) positron emission tomography (PET) tracer, [(11)C]ORM-13070, and the α(2C)-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in healthy humans and in patients with vario...

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Detalles Bibliográficos
Autores principales: Shahid, Mohammed, Rinne, Juha O., Scheinin, Mika, Virta, Jere, Marjamäki, Päivi, Solin, Olof, Arponen, Eveliina, Sallinen, Jukka, Kuokkanen, Katja, Rouru, Juha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726058/
https://www.ncbi.nlm.nih.gov/pubmed/33296042
http://dx.doi.org/10.1186/s13550-020-00741-y

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