Cargando…

Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB

Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as Salmonella and S. aureus, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which requi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rao, Shanshan, Xu, Tao, Xia, Yu, Zhang, Hongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726115/
https://www.ncbi.nlm.nih.gov/pubmed/33324360
http://dx.doi.org/10.3389/fmicb.2020.573844
_version_ 1783620816902029312
author Rao, Shanshan
Xu, Tao
Xia, Yu
Zhang, Hongfeng
author_facet Rao, Shanshan
Xu, Tao
Xia, Yu
Zhang, Hongfeng
author_sort Rao, Shanshan
collection PubMed
description Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as Salmonella and S. aureus, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which require further exploration. Here we identified that Salmonella inhibited the expression and activation of TFEB to blunt the functions of lysosomes and defense of clearance by activating caspase-1. The expression and activation of TFEB were enhanced early under the infection of S. aureus, which was followed by shrinkage to weaken lysosomal functions due to the delayed activation of ERK, mTOR, and STAT3. Thus, we have identified novel escape mechanisms for Salmonella and S. aureus to deepen and strengthen our strategies fighting with pathogens.
format Online
Article
Text
id pubmed-7726115
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77261152020-12-14 Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB Rao, Shanshan Xu, Tao Xia, Yu Zhang, Hongfeng Front Microbiol Microbiology Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as Salmonella and S. aureus, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which require further exploration. Here we identified that Salmonella inhibited the expression and activation of TFEB to blunt the functions of lysosomes and defense of clearance by activating caspase-1. The expression and activation of TFEB were enhanced early under the infection of S. aureus, which was followed by shrinkage to weaken lysosomal functions due to the delayed activation of ERK, mTOR, and STAT3. Thus, we have identified novel escape mechanisms for Salmonella and S. aureus to deepen and strengthen our strategies fighting with pathogens. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7726115/ /pubmed/33324360 http://dx.doi.org/10.3389/fmicb.2020.573844 Text en Copyright © 2020 Rao, Xu, Xia and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Rao, Shanshan
Xu, Tao
Xia, Yu
Zhang, Hongfeng
Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
title Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
title_full Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
title_fullStr Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
title_full_unstemmed Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
title_short Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
title_sort salmonella and s. aureus escape from the clearance of macrophages via controlling tfeb
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726115/
https://www.ncbi.nlm.nih.gov/pubmed/33324360
http://dx.doi.org/10.3389/fmicb.2020.573844
work_keys_str_mv AT raoshanshan salmonellaandsaureusescapefromtheclearanceofmacrophagesviacontrollingtfeb
AT xutao salmonellaandsaureusescapefromtheclearanceofmacrophagesviacontrollingtfeb
AT xiayu salmonellaandsaureusescapefromtheclearanceofmacrophagesviacontrollingtfeb
AT zhanghongfeng salmonellaandsaureusescapefromtheclearanceofmacrophagesviacontrollingtfeb