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Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB
Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as Salmonella and S. aureus, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which requi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726115/ https://www.ncbi.nlm.nih.gov/pubmed/33324360 http://dx.doi.org/10.3389/fmicb.2020.573844 |
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author | Rao, Shanshan Xu, Tao Xia, Yu Zhang, Hongfeng |
author_facet | Rao, Shanshan Xu, Tao Xia, Yu Zhang, Hongfeng |
author_sort | Rao, Shanshan |
collection | PubMed |
description | Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as Salmonella and S. aureus, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which require further exploration. Here we identified that Salmonella inhibited the expression and activation of TFEB to blunt the functions of lysosomes and defense of clearance by activating caspase-1. The expression and activation of TFEB were enhanced early under the infection of S. aureus, which was followed by shrinkage to weaken lysosomal functions due to the delayed activation of ERK, mTOR, and STAT3. Thus, we have identified novel escape mechanisms for Salmonella and S. aureus to deepen and strengthen our strategies fighting with pathogens. |
format | Online Article Text |
id | pubmed-7726115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77261152020-12-14 Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB Rao, Shanshan Xu, Tao Xia, Yu Zhang, Hongfeng Front Microbiol Microbiology Phagosome- and xenophagosome-lysosome systems play a critical role in the defense of pathogenic bacteria, such as Salmonella and S. aureus, in macrophages. A great part of the bacteria escapes from the digestion and can survive through some mechanisms that are still poorly understood and which require further exploration. Here we identified that Salmonella inhibited the expression and activation of TFEB to blunt the functions of lysosomes and defense of clearance by activating caspase-1. The expression and activation of TFEB were enhanced early under the infection of S. aureus, which was followed by shrinkage to weaken lysosomal functions due to the delayed activation of ERK, mTOR, and STAT3. Thus, we have identified novel escape mechanisms for Salmonella and S. aureus to deepen and strengthen our strategies fighting with pathogens. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7726115/ /pubmed/33324360 http://dx.doi.org/10.3389/fmicb.2020.573844 Text en Copyright © 2020 Rao, Xu, Xia and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Rao, Shanshan Xu, Tao Xia, Yu Zhang, Hongfeng Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB |
title | Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB |
title_full | Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB |
title_fullStr | Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB |
title_full_unstemmed | Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB |
title_short | Salmonella and S. aureus Escape From the Clearance of Macrophages via Controlling TFEB |
title_sort | salmonella and s. aureus escape from the clearance of macrophages via controlling tfeb |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726115/ https://www.ncbi.nlm.nih.gov/pubmed/33324360 http://dx.doi.org/10.3389/fmicb.2020.573844 |
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