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Role of Cofilin in Alzheimer’s Disease
Alzheimer’s disease (AD) is a degenerative neurological disease and has an inconspicuous onset and progressive development. Clinically, it is characterized by severe dementia manifestations, including memory impairment, aphasia, apraxia, loss of recognition, impairment of visual-spatial skills, exec...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726191/ https://www.ncbi.nlm.nih.gov/pubmed/33324642 http://dx.doi.org/10.3389/fcell.2020.584898 |
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author | Wang, Qiang Yuan, Wei Yang, Xiaohang Wang, Yuan Li, Yongfeng Qiao, Haifa |
author_facet | Wang, Qiang Yuan, Wei Yang, Xiaohang Wang, Yuan Li, Yongfeng Qiao, Haifa |
author_sort | Wang, Qiang |
collection | PubMed |
description | Alzheimer’s disease (AD) is a degenerative neurological disease and has an inconspicuous onset and progressive development. Clinically, it is characterized by severe dementia manifestations, including memory impairment, aphasia, apraxia, loss of recognition, impairment of visual-spatial skills, executive dysfunction, and changes in personality and behavior. Its etiology is unknown to date. However, several cellular biological signatures of AD have been identified such as synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies which are related to the actin cytoskeleton. Cofilin is one of the most affluent and common actin-binding proteins and plays a role in cell motility, migration, shape, and metabolism. They also play an important role in severing actin filament, nucleating, depolymerizing, and bundling activities. In this review, we summarize the structure of cofilins and their functional and regulating roles, focusing on the synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies of AD. |
format | Online Article Text |
id | pubmed-7726191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77261912020-12-14 Role of Cofilin in Alzheimer’s Disease Wang, Qiang Yuan, Wei Yang, Xiaohang Wang, Yuan Li, Yongfeng Qiao, Haifa Front Cell Dev Biol Cell and Developmental Biology Alzheimer’s disease (AD) is a degenerative neurological disease and has an inconspicuous onset and progressive development. Clinically, it is characterized by severe dementia manifestations, including memory impairment, aphasia, apraxia, loss of recognition, impairment of visual-spatial skills, executive dysfunction, and changes in personality and behavior. Its etiology is unknown to date. However, several cellular biological signatures of AD have been identified such as synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies which are related to the actin cytoskeleton. Cofilin is one of the most affluent and common actin-binding proteins and plays a role in cell motility, migration, shape, and metabolism. They also play an important role in severing actin filament, nucleating, depolymerizing, and bundling activities. In this review, we summarize the structure of cofilins and their functional and regulating roles, focusing on the synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies of AD. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7726191/ /pubmed/33324642 http://dx.doi.org/10.3389/fcell.2020.584898 Text en Copyright © 2020 Wang, Yuan, Yang, Wang, Li and Qiao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Wang, Qiang Yuan, Wei Yang, Xiaohang Wang, Yuan Li, Yongfeng Qiao, Haifa Role of Cofilin in Alzheimer’s Disease |
title | Role of Cofilin in Alzheimer’s Disease |
title_full | Role of Cofilin in Alzheimer’s Disease |
title_fullStr | Role of Cofilin in Alzheimer’s Disease |
title_full_unstemmed | Role of Cofilin in Alzheimer’s Disease |
title_short | Role of Cofilin in Alzheimer’s Disease |
title_sort | role of cofilin in alzheimer’s disease |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726191/ https://www.ncbi.nlm.nih.gov/pubmed/33324642 http://dx.doi.org/10.3389/fcell.2020.584898 |
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