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Role of Cofilin in Alzheimer’s Disease

Alzheimer’s disease (AD) is a degenerative neurological disease and has an inconspicuous onset and progressive development. Clinically, it is characterized by severe dementia manifestations, including memory impairment, aphasia, apraxia, loss of recognition, impairment of visual-spatial skills, exec...

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Autores principales: Wang, Qiang, Yuan, Wei, Yang, Xiaohang, Wang, Yuan, Li, Yongfeng, Qiao, Haifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726191/
https://www.ncbi.nlm.nih.gov/pubmed/33324642
http://dx.doi.org/10.3389/fcell.2020.584898
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author Wang, Qiang
Yuan, Wei
Yang, Xiaohang
Wang, Yuan
Li, Yongfeng
Qiao, Haifa
author_facet Wang, Qiang
Yuan, Wei
Yang, Xiaohang
Wang, Yuan
Li, Yongfeng
Qiao, Haifa
author_sort Wang, Qiang
collection PubMed
description Alzheimer’s disease (AD) is a degenerative neurological disease and has an inconspicuous onset and progressive development. Clinically, it is characterized by severe dementia manifestations, including memory impairment, aphasia, apraxia, loss of recognition, impairment of visual-spatial skills, executive dysfunction, and changes in personality and behavior. Its etiology is unknown to date. However, several cellular biological signatures of AD have been identified such as synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies which are related to the actin cytoskeleton. Cofilin is one of the most affluent and common actin-binding proteins and plays a role in cell motility, migration, shape, and metabolism. They also play an important role in severing actin filament, nucleating, depolymerizing, and bundling activities. In this review, we summarize the structure of cofilins and their functional and regulating roles, focusing on the synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies of AD.
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spelling pubmed-77261912020-12-14 Role of Cofilin in Alzheimer’s Disease Wang, Qiang Yuan, Wei Yang, Xiaohang Wang, Yuan Li, Yongfeng Qiao, Haifa Front Cell Dev Biol Cell and Developmental Biology Alzheimer’s disease (AD) is a degenerative neurological disease and has an inconspicuous onset and progressive development. Clinically, it is characterized by severe dementia manifestations, including memory impairment, aphasia, apraxia, loss of recognition, impairment of visual-spatial skills, executive dysfunction, and changes in personality and behavior. Its etiology is unknown to date. However, several cellular biological signatures of AD have been identified such as synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies which are related to the actin cytoskeleton. Cofilin is one of the most affluent and common actin-binding proteins and plays a role in cell motility, migration, shape, and metabolism. They also play an important role in severing actin filament, nucleating, depolymerizing, and bundling activities. In this review, we summarize the structure of cofilins and their functional and regulating roles, focusing on the synaptic dysfunction, β-amyloid plaques, hyperphosphorylated tau, cofilin-actin rods, and Hirano bodies of AD. Frontiers Media S.A. 2020-11-26 /pmc/articles/PMC7726191/ /pubmed/33324642 http://dx.doi.org/10.3389/fcell.2020.584898 Text en Copyright © 2020 Wang, Yuan, Yang, Wang, Li and Qiao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Wang, Qiang
Yuan, Wei
Yang, Xiaohang
Wang, Yuan
Li, Yongfeng
Qiao, Haifa
Role of Cofilin in Alzheimer’s Disease
title Role of Cofilin in Alzheimer’s Disease
title_full Role of Cofilin in Alzheimer’s Disease
title_fullStr Role of Cofilin in Alzheimer’s Disease
title_full_unstemmed Role of Cofilin in Alzheimer’s Disease
title_short Role of Cofilin in Alzheimer’s Disease
title_sort role of cofilin in alzheimer’s disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726191/
https://www.ncbi.nlm.nih.gov/pubmed/33324642
http://dx.doi.org/10.3389/fcell.2020.584898
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