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Virus-Intrinsic Differences and Heterogeneous IRF3 Activation Influence IFN-Independent Antiviral Protection

Type 1 interferon (IFN) plays a critical role in early antiviral defense and priming of adaptive immunity by signaling upregulation of host antiviral IFN-stimulated genes (ISGs). Certain stimuli trigger strong activation of IFN regulatory factor 3 (IRF3) and direct upregulation of ISGs in addition t...

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Detalles Bibliográficos
Autores principales:	Hare, David N., Baid, Kaushal, Dvorkin-Gheva, Anna, Mossman, Karen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726339/ https://www.ncbi.nlm.nih.gov/pubmed/33319181 http://dx.doi.org/10.1016/j.isci.2020.101864

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