Optimized OPA1 Isoforms 1 and 7 Provide Therapeutic Benefit in Models of Mitochondrial Dysfunction

Optic Atrophy 1 (OPA1) is a mitochondrially targeted GTPase that plays a pivotal role in mitochondrial health, with mutations causing severe mitochondrial dysfunction and typically associated with Dominant Optic Atrophy (DOA), a progressive blinding disease involving retinal ganglion cell loss and o...

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Detalles Bibliográficos
Autores principales: Maloney, Daniel M., Chadderton, Naomi, Millington-Ward, Sophia, Palfi, Arpad, Shortall, Ciara, O’Byrne, James J., Cassidy, Lorraine, Keegan, David, Humphries, Peter, Kenna, Paul, Farrar, Gwyneth Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726421/
https://www.ncbi.nlm.nih.gov/pubmed/33324145
http://dx.doi.org/10.3389/fnins.2020.571479

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