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Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study

PURPOSE: To investigate the impact of the metabolic syndrome (METS) on the incidence of retinal vein occlusion (RVO). METHODS: This is a retrospective cohort study using Korean National Health Insurance System data. 23,153,600 subjects without previous history of RVO underwent a National Health Scre...

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Autores principales: Lim, Dong Hui, Shin, Kyoung Yoon, Han, Kyungdo, Kang, Se Woong, Ham, Don-Il, Kim, Sang Jin, Park, Yong Gyu, Chung, Tae-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726586/
https://www.ncbi.nlm.nih.gov/pubmed/33344059
http://dx.doi.org/10.1167/tvst.9.13.15
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author Lim, Dong Hui
Shin, Kyoung Yoon
Han, Kyungdo
Kang, Se Woong
Ham, Don-Il
Kim, Sang Jin
Park, Yong Gyu
Chung, Tae-Young
author_facet Lim, Dong Hui
Shin, Kyoung Yoon
Han, Kyungdo
Kang, Se Woong
Ham, Don-Il
Kim, Sang Jin
Park, Yong Gyu
Chung, Tae-Young
author_sort Lim, Dong Hui
collection PubMed
description PURPOSE: To investigate the impact of the metabolic syndrome (METS) on the incidence of retinal vein occlusion (RVO). METHODS: This is a retrospective cohort study using Korean National Health Insurance System data. 23,153,600 subjects without previous history of RVO underwent a National Health Screening Program examination between 2009 and 2012. They were monitored for RVO development (registration of diagnostic code for RVO) until 2015. Presence of METS was defined using the data from the National Health Screening Program examination according to the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III. A multivariate adjusted Cox regression analysis was used to reveal hazard ratios and 95% confidence interval for RVO development in the presence of METS. RESULTS: The age of the subjects was 47.64 ± 13.51 years. In this cohort, 11,747,439 (50.7%) were male, 11,406,161 (49.3%) were female, and 6,398,071 subjects (27.6%) were diagnosed with METS. The overall incidence of RVO was 0.947 per 1000 person-years. The adjusted hazard ratio of RVO in the presence of METS was 1.458 (95% confidence interval, 1.440–1.475; P < 0.001) after adjusting for age, sex, smoking status, alcohol consumption, physical activity, and income. Among all of the criteria for METS diagnosis, elevated blood pressure was the greatest risk for RVO development (adjusted hazard ratio, 1.610; 95% confidence interval, 1.589–1.631; P < 0.001). CONCLUSIONS: METS and each of diagnostic criteria was associated with an increased risk of RVO development. Elevated blood pressure seems to be especially important factors for RVO development. TRANSLATIONAL RELEVANCE: Our results provide information about the link between METS and RVO.
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spelling pubmed-77265862020-12-17 Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study Lim, Dong Hui Shin, Kyoung Yoon Han, Kyungdo Kang, Se Woong Ham, Don-Il Kim, Sang Jin Park, Yong Gyu Chung, Tae-Young Transl Vis Sci Technol Article PURPOSE: To investigate the impact of the metabolic syndrome (METS) on the incidence of retinal vein occlusion (RVO). METHODS: This is a retrospective cohort study using Korean National Health Insurance System data. 23,153,600 subjects without previous history of RVO underwent a National Health Screening Program examination between 2009 and 2012. They were monitored for RVO development (registration of diagnostic code for RVO) until 2015. Presence of METS was defined using the data from the National Health Screening Program examination according to the revised criteria of the National Cholesterol Education Program Adult Treatment Panel III. A multivariate adjusted Cox regression analysis was used to reveal hazard ratios and 95% confidence interval for RVO development in the presence of METS. RESULTS: The age of the subjects was 47.64 ± 13.51 years. In this cohort, 11,747,439 (50.7%) were male, 11,406,161 (49.3%) were female, and 6,398,071 subjects (27.6%) were diagnosed with METS. The overall incidence of RVO was 0.947 per 1000 person-years. The adjusted hazard ratio of RVO in the presence of METS was 1.458 (95% confidence interval, 1.440–1.475; P < 0.001) after adjusting for age, sex, smoking status, alcohol consumption, physical activity, and income. Among all of the criteria for METS diagnosis, elevated blood pressure was the greatest risk for RVO development (adjusted hazard ratio, 1.610; 95% confidence interval, 1.589–1.631; P < 0.001). CONCLUSIONS: METS and each of diagnostic criteria was associated with an increased risk of RVO development. Elevated blood pressure seems to be especially important factors for RVO development. TRANSLATIONAL RELEVANCE: Our results provide information about the link between METS and RVO. The Association for Research in Vision and Ophthalmology 2020-12-08 /pmc/articles/PMC7726586/ /pubmed/33344059 http://dx.doi.org/10.1167/tvst.9.13.15 Text en Copyright 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Article
Lim, Dong Hui
Shin, Kyoung Yoon
Han, Kyungdo
Kang, Se Woong
Ham, Don-Il
Kim, Sang Jin
Park, Yong Gyu
Chung, Tae-Young
Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study
title Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study
title_full Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study
title_fullStr Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study
title_full_unstemmed Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study
title_short Differential Effect of the Metabolic Syndrome on the Incidence of Retinal Vein Occlusion in the Korean Population: A Nationwide Cohort Study
title_sort differential effect of the metabolic syndrome on the incidence of retinal vein occlusion in the korean population: a nationwide cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726586/
https://www.ncbi.nlm.nih.gov/pubmed/33344059
http://dx.doi.org/10.1167/tvst.9.13.15
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