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Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study

INTRODUCTION: In Italy, the real-world evidence on the extent of adherence to guidelines and the benefits of recommended therapeutic medications and their impact on the quality of life (QoL) of H(1)-antihistamines (H(1)-AH) refractory chronic urticaria (CU) patients is limited. METHODS: AWARE (A Wor...

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Autores principales: Rossi, Oliviero, Piccirillo, Angelo, Iemoli, Enrico, Patrizi, Annalisa, Stingeni, Luca, Calvieri, Stefano, Gola, Massimo, Dapavo, Paolo, Cristaudo, Antonio, Zichichi, Leonardo, Losappio, Laura, Saccheri, Fabiana, Pastorello, Elide Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726718/
https://www.ncbi.nlm.nih.gov/pubmed/33343800
http://dx.doi.org/10.1016/j.waojou.2020.100470
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author Rossi, Oliviero
Piccirillo, Angelo
Iemoli, Enrico
Patrizi, Annalisa
Stingeni, Luca
Calvieri, Stefano
Gola, Massimo
Dapavo, Paolo
Cristaudo, Antonio
Zichichi, Leonardo
Losappio, Laura
Saccheri, Fabiana
Pastorello, Elide Anna
author_facet Rossi, Oliviero
Piccirillo, Angelo
Iemoli, Enrico
Patrizi, Annalisa
Stingeni, Luca
Calvieri, Stefano
Gola, Massimo
Dapavo, Paolo
Cristaudo, Antonio
Zichichi, Leonardo
Losappio, Laura
Saccheri, Fabiana
Pastorello, Elide Anna
author_sort Rossi, Oliviero
collection PubMed
description INTRODUCTION: In Italy, the real-world evidence on the extent of adherence to guidelines and the benefits of recommended therapeutic medications and their impact on the quality of life (QoL) of H(1)-antihistamines (H(1)-AH) refractory chronic urticaria (CU) patients is limited. METHODS: AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) was a global prospective, non-interventional study of CU in real-world setting which included patients aged ≥18 years with a medically confirmed diagnosed of CU present for more than 2 months. In this study, the disease characteristics, pharmacological treatments and patient-reported outcomes (PROs) are reported. RESULTS: In total, 159 patients from 24 study centres in Italy completed the study. At baseline, 221 (89.5%) and 8 (3.2%) patients had chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), respectively, while 18 (7.3%) patients had concomitant CSU and CIndU. For CSU patients, mean dermatology life quality index and CU quality of life questionnaire scores reduced to 3.0 ± 4.9 and 14.6 ± 18.6 at Month 24 from baseline scores of 7.5 ± 6.6 and 33.2 ± 19.5, respectively, indicating an improvement in QoL. This was reflected in their work-life as work productivity impairment reduced considerably after 2 years. Only 71.9% CSU patients had a prior treatment, while during the study, 96.8% of the patients were treated with a medication. At baseline, only 52.9% CSU patients reported nonsedating H(1)-antihistamines as first-line of treatment in prior medication, this increased to 89.6% during current medication. CONCLUSION: This study shows that CSU has a considerable socio-economic burden and an improvement in QoL can be achieved in CSU patients if an appropriate therapeutic path is followed.
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spelling pubmed-77267182020-12-18 Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study Rossi, Oliviero Piccirillo, Angelo Iemoli, Enrico Patrizi, Annalisa Stingeni, Luca Calvieri, Stefano Gola, Massimo Dapavo, Paolo Cristaudo, Antonio Zichichi, Leonardo Losappio, Laura Saccheri, Fabiana Pastorello, Elide Anna World Allergy Organ J Article INTRODUCTION: In Italy, the real-world evidence on the extent of adherence to guidelines and the benefits of recommended therapeutic medications and their impact on the quality of life (QoL) of H(1)-antihistamines (H(1)-AH) refractory chronic urticaria (CU) patients is limited. METHODS: AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) was a global prospective, non-interventional study of CU in real-world setting which included patients aged ≥18 years with a medically confirmed diagnosed of CU present for more than 2 months. In this study, the disease characteristics, pharmacological treatments and patient-reported outcomes (PROs) are reported. RESULTS: In total, 159 patients from 24 study centres in Italy completed the study. At baseline, 221 (89.5%) and 8 (3.2%) patients had chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), respectively, while 18 (7.3%) patients had concomitant CSU and CIndU. For CSU patients, mean dermatology life quality index and CU quality of life questionnaire scores reduced to 3.0 ± 4.9 and 14.6 ± 18.6 at Month 24 from baseline scores of 7.5 ± 6.6 and 33.2 ± 19.5, respectively, indicating an improvement in QoL. This was reflected in their work-life as work productivity impairment reduced considerably after 2 years. Only 71.9% CSU patients had a prior treatment, while during the study, 96.8% of the patients were treated with a medication. At baseline, only 52.9% CSU patients reported nonsedating H(1)-antihistamines as first-line of treatment in prior medication, this increased to 89.6% during current medication. CONCLUSION: This study shows that CSU has a considerable socio-economic burden and an improvement in QoL can be achieved in CSU patients if an appropriate therapeutic path is followed. World Allergy Organization 2020-12-08 /pmc/articles/PMC7726718/ /pubmed/33343800 http://dx.doi.org/10.1016/j.waojou.2020.100470 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rossi, Oliviero
Piccirillo, Angelo
Iemoli, Enrico
Patrizi, Annalisa
Stingeni, Luca
Calvieri, Stefano
Gola, Massimo
Dapavo, Paolo
Cristaudo, Antonio
Zichichi, Leonardo
Losappio, Laura
Saccheri, Fabiana
Pastorello, Elide Anna
Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study
title Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study
title_full Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study
title_fullStr Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study
title_full_unstemmed Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study
title_short Socio-economic burden and resource utilisation in Italian patients with chronic urticaria: 2-year data from the AWARE study
title_sort socio-economic burden and resource utilisation in italian patients with chronic urticaria: 2-year data from the aware study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726718/
https://www.ncbi.nlm.nih.gov/pubmed/33343800
http://dx.doi.org/10.1016/j.waojou.2020.100470
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