Thrombotic Microangiopathy in a Kidney Transplant Patient With COVID-19

Kidney transplant recipients are at increased risk for infection, including coronavirus disease 2019 (COVID-19), given ongoing immunosuppression. In individuals with COVID-19, complications including thrombosis and endothelial dysfunction portend worse outcomes. In this report, we describe a kidney...

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Detalles Bibliográficos
Autores principales: Bascuñana, Arturo, Mijaylova, Antonia, Vega, Almudena, Macías, Nicolás, Verde, Eduardo, Rodríguez-Ferrero, Maria Luisa, Delgado, Andrés, Carbayo, Javier, Goicoechea, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726739/
https://www.ncbi.nlm.nih.gov/pubmed/33319192
http://dx.doi.org/10.1016/j.xkme.2020.09.014
Descripción
Sumario:Kidney transplant recipients are at increased risk for infection, including coronavirus disease 2019 (COVID-19), given ongoing immunosuppression. In individuals with COVID-19, complications including thrombosis and endothelial dysfunction portend worse outcomes. In this report, we describe a kidney transplant recipient who developed severe thrombotic microangiopathy with a low platelet count (12 ×10(9)/L), anemia (hemoglobin, 7.5 g/dL with 7% schistocytes on peripheral-blood smear), and severe acute kidney injury concurrent with COVID-19. The clinical course improved after plasma exchange. Given this presentation, we hypothesize that COVID-19 triggered thrombotic microangiopathy.

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