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Supercomplex formation boosts respiration
Mitochondrial respiratory chain complexes associate in supercomplexes, but the physiological role of these assemblies remains controversial. Recent studies in EMBO Reports reveal that supercomplexes promote metabolic fitness. Berndtsson et al (2020) demonstrate that supercomplex formation enhances e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726771/ https://www.ncbi.nlm.nih.gov/pubmed/33270972 http://dx.doi.org/10.15252/embr.202051830 |
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author | den Brave, Fabian Becker, Thomas |
author_facet | den Brave, Fabian Becker, Thomas |
author_sort | den Brave, Fabian |
collection | PubMed |
description | Mitochondrial respiratory chain complexes associate in supercomplexes, but the physiological role of these assemblies remains controversial. Recent studies in EMBO Reports reveal that supercomplexes promote metabolic fitness. Berndtsson et al (2020) demonstrate that supercomplex formation enhances electron transport by reducing the distance for diffusion of cytochrome c between cytochrome bc(1) complex and cytochrome c oxidase and thereby increases competitive fitness in yeast. Similarly, Garcia‐Poyatos et al (2020) report that zebrafish lacking the supercomplex assembly factor SCAF1 display a reduced growth and decreased female fertility. |
format | Online Article Text |
id | pubmed-7726771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77267712021-11-23 Supercomplex formation boosts respiration den Brave, Fabian Becker, Thomas EMBO Rep News & Views Mitochondrial respiratory chain complexes associate in supercomplexes, but the physiological role of these assemblies remains controversial. Recent studies in EMBO Reports reveal that supercomplexes promote metabolic fitness. Berndtsson et al (2020) demonstrate that supercomplex formation enhances electron transport by reducing the distance for diffusion of cytochrome c between cytochrome bc(1) complex and cytochrome c oxidase and thereby increases competitive fitness in yeast. Similarly, Garcia‐Poyatos et al (2020) report that zebrafish lacking the supercomplex assembly factor SCAF1 display a reduced growth and decreased female fertility. John Wiley and Sons Inc. 2020-12-03 2020-12-03 /pmc/articles/PMC7726771/ /pubmed/33270972 http://dx.doi.org/10.15252/embr.202051830 Text en © 2020 The Authors. Published under the terms of the CC BY NC ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | News & Views den Brave, Fabian Becker, Thomas Supercomplex formation boosts respiration |
title | Supercomplex formation boosts respiration |
title_full | Supercomplex formation boosts respiration |
title_fullStr | Supercomplex formation boosts respiration |
title_full_unstemmed | Supercomplex formation boosts respiration |
title_short | Supercomplex formation boosts respiration |
title_sort | supercomplex formation boosts respiration |
topic | News & Views |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726771/ https://www.ncbi.nlm.nih.gov/pubmed/33270972 http://dx.doi.org/10.15252/embr.202051830 |
work_keys_str_mv | AT denbravefabian supercomplexformationboostsrespiration AT beckerthomas supercomplexformationboostsrespiration |