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Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria

Although tuberculosis is a major underlying cause of pulmonary mycetoma due to Scedosporium apiospermum, little is known about coinfection with nontuberculous mycobacteria (NTM) and S. apiospermum. A 67‐year‐old man with NTM presented with recurrent haemoptysis. Computed tomography of the chest reve...

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Autores principales: Ogata, Hiroaki, Harada, Eiji, Okamoto, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726778/
https://www.ncbi.nlm.nih.gov/pubmed/33318800
http://dx.doi.org/10.1002/rcr2.691
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author Ogata, Hiroaki
Harada, Eiji
Okamoto, Isamu
author_facet Ogata, Hiroaki
Harada, Eiji
Okamoto, Isamu
author_sort Ogata, Hiroaki
collection PubMed
description Although tuberculosis is a major underlying cause of pulmonary mycetoma due to Scedosporium apiospermum, little is known about coinfection with nontuberculous mycobacteria (NTM) and S. apiospermum. A 67‐year‐old man with NTM presented with recurrent haemoptysis. Computed tomography of the chest revealed pulmonary mycetoma in the left upper lobe of the lung, and culture of bronchial washing fluid yielded S. apiospermum. Oral voriconazole therapy ameliorated both haemoptysis and mycetoma findings. As far as we are aware, this is the first reported case of S. apiospermum lung disease in a patient with NTM but without tuberculosis. The possibility of S. apiospermum infection should thus be considered in the differential diagnosis of pulmonary mycetoma. Although S. apiospermum mycetoma resembles aspergilloma, antifungal strategies for these two conditions differ, with the collection of culture specimens such as by bronchoscopy being compulsory for accurate diagnosis and appropriate management of S. apiospermum infection.
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spelling pubmed-77267782020-12-13 Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria Ogata, Hiroaki Harada, Eiji Okamoto, Isamu Respirol Case Rep Case Reports Although tuberculosis is a major underlying cause of pulmonary mycetoma due to Scedosporium apiospermum, little is known about coinfection with nontuberculous mycobacteria (NTM) and S. apiospermum. A 67‐year‐old man with NTM presented with recurrent haemoptysis. Computed tomography of the chest revealed pulmonary mycetoma in the left upper lobe of the lung, and culture of bronchial washing fluid yielded S. apiospermum. Oral voriconazole therapy ameliorated both haemoptysis and mycetoma findings. As far as we are aware, this is the first reported case of S. apiospermum lung disease in a patient with NTM but without tuberculosis. The possibility of S. apiospermum infection should thus be considered in the differential diagnosis of pulmonary mycetoma. Although S. apiospermum mycetoma resembles aspergilloma, antifungal strategies for these two conditions differ, with the collection of culture specimens such as by bronchoscopy being compulsory for accurate diagnosis and appropriate management of S. apiospermum infection. John Wiley & Sons, Ltd 2020-12-10 /pmc/articles/PMC7726778/ /pubmed/33318800 http://dx.doi.org/10.1002/rcr2.691 Text en © 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Ogata, Hiroaki
Harada, Eiji
Okamoto, Isamu
Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
title Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
title_full Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
title_fullStr Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
title_full_unstemmed Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
title_short Scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
title_sort scedosporium apiospermum lung disease in a patient with nontuberculous mycobacteria
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726778/
https://www.ncbi.nlm.nih.gov/pubmed/33318800
http://dx.doi.org/10.1002/rcr2.691
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