PIDDosome‐induced p53‐dependent ploidy restriction facilitates hepatocarcinogenesis

Polyploidization frequently precedes tumorigenesis but also occurs during normal development in several tissues. Hepatocyte ploidy is controlled by the PIDDosome during development and regeneration. This multi‐protein complex is activated by supernumerary centrosomes to induce p53 and restrict proli...

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Detalles Bibliográficos
Autores principales: Sladky, Valentina C, Knapp, Katja, Szabo, Tamas G, Braun, Vincent Z, Bongiovanni, Laura, van den Bos, Hilda, Spierings, Diana CJ, Westendorp, Bart, Curinha, Ana, Stojakovic, Tatjana, Scharnagl, Hubert, Timelthaler, Gerald, Tsuchia, Kaoru, Pinter, Matthias, Semmler, Georg, Foijer, Floris, de Bruin, Alain, Reiberger, Thomas, Rohr‐Udilova, Nataliya, Villunger, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726793/
https://www.ncbi.nlm.nih.gov/pubmed/33225610
http://dx.doi.org/10.15252/embr.202050893

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