Increased Association of Deamidated αA-(N101D) with Lens membrane of transgenic αA(N101D) vs. wild type αA mice: potential effects on intracellular ionic imbalance and membrane disorganization

ABSTRACT: We have generated two mouse models, in one by inserting the human lens αAN101D transgene in CRYαA(N101D) mice, and in the other by inserting human wild-type αA-transgene in CRYαA(WT) mice. The CRYαA(N101D) mice developed cortical cataract at about 7-months of age relative to CRYαA(WT) mice...

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Detalles Bibliográficos
Autores principales: Srivastava, Om, Srivastava, Kiran, Joseph, Roy, Wilson, Landon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726915/
https://www.ncbi.nlm.nih.gov/pubmed/33302904
http://dx.doi.org/10.1186/s12886-020-01734-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726915/
https://www.ncbi.nlm.nih.gov/pubmed/33302904
http://dx.doi.org/10.1186/s12886-020-01734-0

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