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Increased Association of Deamidated αA-(N101D) with Lens membrane of transgenic αA(N101D) vs. wild type αA mice: potential effects on intracellular ionic imbalance and membrane disorganization
ABSTRACT: We have generated two mouse models, in one by inserting the human lens αAN101D transgene in CRYαA(N101D) mice, and in the other by inserting human wild-type αA-transgene in CRYαA(WT) mice. The CRYαA(N101D) mice developed cortical cataract at about 7-months of age relative to CRYαA(WT) mice...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7726915/ https://www.ncbi.nlm.nih.gov/pubmed/33302904 http://dx.doi.org/10.1186/s12886-020-01734-0 |