Cargando…
Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders
BACKGROUND: Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. METHODS: Subjects consisted of...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727241/ https://www.ncbi.nlm.nih.gov/pubmed/33302965 http://dx.doi.org/10.1186/s12991-020-00318-y |
_version_ | 1783621061659590656 |
---|---|
author | Wang, Pengshuo Zhang, Ran Jiang, Xiaowei Wei, Shengnan Wang, Fei Tang, Yanqing |
author_facet | Wang, Pengshuo Zhang, Ran Jiang, Xiaowei Wei, Shengnan Wang, Fei Tang, Yanqing |
author_sort | Wang, Pengshuo |
collection | PubMed |
description | BACKGROUND: Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. METHODS: Subjects consisted of 70 patients with mood disorders and suicidal behavior, 128 patients with mood disorders without suicidal behavior (mood disorders control, MC), and 145 health control (HC) individuals. All participants underwent structural magnetic resonance imaging (MRI). We used voxel-based morphometry (VBM) techniques to examine gray matter volumes (GMVs). RESULTS: Significant differences were found in GMVs of the left and right middle frontal gyrus among the patients with mood disorders and suicidal behavior, MC, and HC. Post hoc comparisons showed significant differences in the GMVs of the above regions across all three groups (P < 0.01): HC > MC > mood disorders with suicidal behavior. However, there were no significant differences in the GMVs of the left and right middle frontal gyrus between the mood disorders with SI and mood disorders with SAs groups. CONCLUSIONS: These findings provide evidence that abnormal regional GMV in the middle frontal gyrus is associated with suicidal behavior in mood disorders. Further investigation is warranted to determine whether the GMV alterations in mood disorders with SI are different from these in mood disorders with SAs. |
format | Online Article Text |
id | pubmed-7727241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77272412020-12-11 Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders Wang, Pengshuo Zhang, Ran Jiang, Xiaowei Wei, Shengnan Wang, Fei Tang, Yanqing Ann Gen Psychiatry Primary Research BACKGROUND: Mood disorders are severe mental disorders related to increased suicidal behavior. Finding neural features for suicidal behavior, including suicide attempts (SAs) and suicidal ideation (SI), in mood disorders may be helpful in preventing suicidal behavior. METHODS: Subjects consisted of 70 patients with mood disorders and suicidal behavior, 128 patients with mood disorders without suicidal behavior (mood disorders control, MC), and 145 health control (HC) individuals. All participants underwent structural magnetic resonance imaging (MRI). We used voxel-based morphometry (VBM) techniques to examine gray matter volumes (GMVs). RESULTS: Significant differences were found in GMVs of the left and right middle frontal gyrus among the patients with mood disorders and suicidal behavior, MC, and HC. Post hoc comparisons showed significant differences in the GMVs of the above regions across all three groups (P < 0.01): HC > MC > mood disorders with suicidal behavior. However, there were no significant differences in the GMVs of the left and right middle frontal gyrus between the mood disorders with SI and mood disorders with SAs groups. CONCLUSIONS: These findings provide evidence that abnormal regional GMV in the middle frontal gyrus is associated with suicidal behavior in mood disorders. Further investigation is warranted to determine whether the GMV alterations in mood disorders with SI are different from these in mood disorders with SAs. BioMed Central 2020-12-10 /pmc/articles/PMC7727241/ /pubmed/33302965 http://dx.doi.org/10.1186/s12991-020-00318-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Primary Research Wang, Pengshuo Zhang, Ran Jiang, Xiaowei Wei, Shengnan Wang, Fei Tang, Yanqing Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
title | Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
title_full | Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
title_fullStr | Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
title_full_unstemmed | Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
title_short | Gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
title_sort | gray matter volume alterations associated with suicidal ideation and suicide attempts in patients with mood disorders |
topic | Primary Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727241/ https://www.ncbi.nlm.nih.gov/pubmed/33302965 http://dx.doi.org/10.1186/s12991-020-00318-y |
work_keys_str_mv | AT wangpengshuo graymattervolumealterationsassociatedwithsuicidalideationandsuicideattemptsinpatientswithmooddisorders AT zhangran graymattervolumealterationsassociatedwithsuicidalideationandsuicideattemptsinpatientswithmooddisorders AT jiangxiaowei graymattervolumealterationsassociatedwithsuicidalideationandsuicideattemptsinpatientswithmooddisorders AT weishengnan graymattervolumealterationsassociatedwithsuicidalideationandsuicideattemptsinpatientswithmooddisorders AT wangfei graymattervolumealterationsassociatedwithsuicidalideationandsuicideattemptsinpatientswithmooddisorders AT tangyanqing graymattervolumealterationsassociatedwithsuicidalideationandsuicideattemptsinpatientswithmooddisorders |