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MiR-218 affects hypertrophic differentiation of human mesenchymal stromal cells during chondrogenesis via targeting RUNX2, MEF2C, and COL10A1

BACKGROUND: Human mesenchymal stromal cells (MSC) hold hopes for cartilage regenerative therapy due to their chondrogenic differentiation potential. However, undesirable occurrence of calcification after ectopic transplantation, known as hypertrophic degeneration, remains the major obstacle limiting...

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Detalles Bibliográficos
Autores principales:	Melnik, Svitlana, Gabler, Jessica, Dreher, Simon I., Hecht, Nicole, Hofmann, Nina, Großner, Tobias, Richter, Wiltrud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727242/ https://www.ncbi.nlm.nih.gov/pubmed/33303006 http://dx.doi.org/10.1186/s13287-020-02026-6

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