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Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727463/ https://www.ncbi.nlm.nih.gov/pubmed/33336137 http://dx.doi.org/10.1097/EE9.0000000000000123 |
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author | Furlong, Melissa A. Paul, Kimberly C. Cockburn, Myles Bronstein, Jeff Keener, Adrienne Rosario, Irish Del Folle, Aline Duarte Ritz, Beate |
author_facet | Furlong, Melissa A. Paul, Kimberly C. Cockburn, Myles Bronstein, Jeff Keener, Adrienne Rosario, Irish Del Folle, Aline Duarte Ritz, Beate |
author_sort | Furlong, Melissa A. |
collection | PubMed |
description | Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures in central California, using two waves (PEG 1&2, total N = 1,654) of a case control study of Parkinson’s disease (PD). At enrollment, participants self-reported history of use of depression medications and dates of MD-diagnosed depression and anxiety. Participants also completed a Geriatric Depression Scale-Short Form upon enrollment. We used the California Pesticide Use Registry to assign estimated ambient pyrethroid pesticide exposures at participant’s home addresses over the 5 years before the index date (date of outcome, or an age-matched year for participants without the outcome). We used logistic and linear regression to evaluate associations between living near any pyrethroid applications over the 5-year index period and measures of depression and anxiety. We also evaluated modification by study wave and PD status. We observed associations of pyrethroids with depression, depression medications, and anxiety (adjusted odds ratio [aOR] depression = 1.54, 95% confidence interval [CI] 1.14, 2.07; aOR depression medications = 1.68, 95% CI 1.25, 2.25; aOR anxiety = 1.60, 95% CI 1.17, 2.18). However, we observed no associations with mild/moderate depressive symptoms according to the GDS score at enrollment (aOR = 1.04, 95% CI 0.77, 1.42). We did not observe a consistent modification of the pyrethroid-depression associations by study wave and PD status. Ambient pyrethroid pesticide exposures may be associated with measures of depression in later life. |
format | Online Article Text |
id | pubmed-7727463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-77274632020-12-15 Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley Furlong, Melissa A. Paul, Kimberly C. Cockburn, Myles Bronstein, Jeff Keener, Adrienne Rosario, Irish Del Folle, Aline Duarte Ritz, Beate Environ Epidemiol Original Research Article Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures in central California, using two waves (PEG 1&2, total N = 1,654) of a case control study of Parkinson’s disease (PD). At enrollment, participants self-reported history of use of depression medications and dates of MD-diagnosed depression and anxiety. Participants also completed a Geriatric Depression Scale-Short Form upon enrollment. We used the California Pesticide Use Registry to assign estimated ambient pyrethroid pesticide exposures at participant’s home addresses over the 5 years before the index date (date of outcome, or an age-matched year for participants without the outcome). We used logistic and linear regression to evaluate associations between living near any pyrethroid applications over the 5-year index period and measures of depression and anxiety. We also evaluated modification by study wave and PD status. We observed associations of pyrethroids with depression, depression medications, and anxiety (adjusted odds ratio [aOR] depression = 1.54, 95% confidence interval [CI] 1.14, 2.07; aOR depression medications = 1.68, 95% CI 1.25, 2.25; aOR anxiety = 1.60, 95% CI 1.17, 2.18). However, we observed no associations with mild/moderate depressive symptoms according to the GDS score at enrollment (aOR = 1.04, 95% CI 0.77, 1.42). We did not observe a consistent modification of the pyrethroid-depression associations by study wave and PD status. Ambient pyrethroid pesticide exposures may be associated with measures of depression in later life. Lippincott Williams & Wilkins 2020-12-02 /pmc/articles/PMC7727463/ /pubmed/33336137 http://dx.doi.org/10.1097/EE9.0000000000000123 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Original Research Article Furlong, Melissa A. Paul, Kimberly C. Cockburn, Myles Bronstein, Jeff Keener, Adrienne Rosario, Irish Del Folle, Aline Duarte Ritz, Beate Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley |
title | Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley |
title_full | Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley |
title_fullStr | Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley |
title_full_unstemmed | Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley |
title_short | Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley |
title_sort | ambient pyrethroid pesticide exposures in adult life and depression in older residents of california’s central valley |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727463/ https://www.ncbi.nlm.nih.gov/pubmed/33336137 http://dx.doi.org/10.1097/EE9.0000000000000123 |
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