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Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley

Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures...

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Autores principales: Furlong, Melissa A., Paul, Kimberly C., Cockburn, Myles, Bronstein, Jeff, Keener, Adrienne, Rosario, Irish Del, Folle, Aline Duarte, Ritz, Beate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727463/
https://www.ncbi.nlm.nih.gov/pubmed/33336137
http://dx.doi.org/10.1097/EE9.0000000000000123
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author Furlong, Melissa A.
Paul, Kimberly C.
Cockburn, Myles
Bronstein, Jeff
Keener, Adrienne
Rosario, Irish Del
Folle, Aline Duarte
Ritz, Beate
author_facet Furlong, Melissa A.
Paul, Kimberly C.
Cockburn, Myles
Bronstein, Jeff
Keener, Adrienne
Rosario, Irish Del
Folle, Aline Duarte
Ritz, Beate
author_sort Furlong, Melissa A.
collection PubMed
description Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures in central California, using two waves (PEG 1&2, total N = 1,654) of a case control study of Parkinson’s disease (PD). At enrollment, participants self-reported history of use of depression medications and dates of MD-diagnosed depression and anxiety. Participants also completed a Geriatric Depression Scale-Short Form upon enrollment. We used the California Pesticide Use Registry to assign estimated ambient pyrethroid pesticide exposures at participant’s home addresses over the 5 years before the index date (date of outcome, or an age-matched year for participants without the outcome). We used logistic and linear regression to evaluate associations between living near any pyrethroid applications over the 5-year index period and measures of depression and anxiety. We also evaluated modification by study wave and PD status. We observed associations of pyrethroids with depression, depression medications, and anxiety (adjusted odds ratio [aOR] depression = 1.54, 95% confidence interval [CI] 1.14, 2.07; aOR depression medications = 1.68, 95% CI 1.25, 2.25; aOR anxiety = 1.60, 95% CI 1.17, 2.18). However, we observed no associations with mild/moderate depressive symptoms according to the GDS score at enrollment (aOR = 1.04, 95% CI 0.77, 1.42). We did not observe a consistent modification of the pyrethroid-depression associations by study wave and PD status. Ambient pyrethroid pesticide exposures may be associated with measures of depression in later life.
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spelling pubmed-77274632020-12-15 Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley Furlong, Melissa A. Paul, Kimberly C. Cockburn, Myles Bronstein, Jeff Keener, Adrienne Rosario, Irish Del Folle, Aline Duarte Ritz, Beate Environ Epidemiol Original Research Article Pyrethroid pesticide exposures may be associated with the onset of depression in later life via disruption of dopaminergic, serotonergic, and neurological functioning. We sought to investigate the association between living near agricultural pyrethroid pesticide applications and depression measures in central California, using two waves (PEG 1&2, total N = 1,654) of a case control study of Parkinson’s disease (PD). At enrollment, participants self-reported history of use of depression medications and dates of MD-diagnosed depression and anxiety. Participants also completed a Geriatric Depression Scale-Short Form upon enrollment. We used the California Pesticide Use Registry to assign estimated ambient pyrethroid pesticide exposures at participant’s home addresses over the 5 years before the index date (date of outcome, or an age-matched year for participants without the outcome). We used logistic and linear regression to evaluate associations between living near any pyrethroid applications over the 5-year index period and measures of depression and anxiety. We also evaluated modification by study wave and PD status. We observed associations of pyrethroids with depression, depression medications, and anxiety (adjusted odds ratio [aOR] depression = 1.54, 95% confidence interval [CI] 1.14, 2.07; aOR depression medications = 1.68, 95% CI 1.25, 2.25; aOR anxiety = 1.60, 95% CI 1.17, 2.18). However, we observed no associations with mild/moderate depressive symptoms according to the GDS score at enrollment (aOR = 1.04, 95% CI 0.77, 1.42). We did not observe a consistent modification of the pyrethroid-depression associations by study wave and PD status. Ambient pyrethroid pesticide exposures may be associated with measures of depression in later life. Lippincott Williams & Wilkins 2020-12-02 /pmc/articles/PMC7727463/ /pubmed/33336137 http://dx.doi.org/10.1097/EE9.0000000000000123 Text en Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The Environmental Epidemiology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Original Research Article
Furlong, Melissa A.
Paul, Kimberly C.
Cockburn, Myles
Bronstein, Jeff
Keener, Adrienne
Rosario, Irish Del
Folle, Aline Duarte
Ritz, Beate
Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
title Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
title_full Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
title_fullStr Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
title_full_unstemmed Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
title_short Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley
title_sort ambient pyrethroid pesticide exposures in adult life and depression in older residents of california’s central valley
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727463/
https://www.ncbi.nlm.nih.gov/pubmed/33336137
http://dx.doi.org/10.1097/EE9.0000000000000123
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