The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer’s Disease: A Preclinical Study in APP/PS1 Transgenic Mice

BACKGROUND: Depression is highly related to Alzheimer’s disease (AD), yet no effective treatment is available. Phosphodiesterase-4 (PDE4) has been considered a promising target for treatment of AD and depression. Roflumilast, the first PDE4 inhibitor approved for clinical use, improves cognition at...

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Detalles Bibliográficos
Autores principales: Wang, Hao, Zhang, Fang-fang, Xu, Yong, Fu, Hua-rong, Wang, Xiao-dan, Wang, Lei, Chen, Wei, Xu, Xiao-yan, Gao, Yong-feng, Zhang, Ji-guo, Zhang, Han-Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Regular Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727475/
https://www.ncbi.nlm.nih.gov/pubmed/32645141
http://dx.doi.org/10.1093/ijnp/pyaa048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7727475/
https://www.ncbi.nlm.nih.gov/pubmed/32645141
http://dx.doi.org/10.1093/ijnp/pyaa048

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